Banca de QUALIFICAÇÃO: ADJANNA KARLA LEITE ARAÚJO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ADJANNA KARLA LEITE ARAÚJO
DATE: 30/06/2025
TIME: 14:00
LOCAL: Google Meet
TITLE:

PHARMACEUTICAL COMPOSITION OF A TOPICAL FORMULATION BASED ON CANNABIDIOL, QUERCETIN AND PENTRAVAN® FOR THE TREATMENT OF ATOPIC DERMATITIS

KEY WORDS:

Cannabidiol; Quercetin; Canine atopic dermatitis; Pentravan®; Endocannabinoid system; Cutaneous inflammation; Topical therapy; Murine model.

PAGES: 120
BIG AREA: Outra
AREA: Multidisciplinar
SUBÁREA: Biotecnologia
SUMMARY:

Canine atopic dermatitis (CAD) is a chronic and relapsing inflammatory disease with an immunomediated basis, characterized by epidermal barrier dysfunction and activation of Th2 immune pathways. Although conventional treatments are effective, they are often associated with adverse effects, high costs, and therapeutic resistance, highlighting the need for safer and more effective alternative approaches. In this context, this doctoral thesis aimed to evaluate the therapeutic potential of the topical application of cannabidiol (CBD), quercetin (QU), and the transdermal vehicle Pentravan®, alone and in combination, using a murine experimental model of atopic dermatitis. Clinical, macroscopic, thermographic, histopathological, and immunological analyses were conducted to assess the formulations effects on cutaneous inflammation, epidermal integrity, immune response profile, and clinical evolution. The results showed that the association of CBD + QU + Pentravan® significantly improved clinical signs and inflammatory parameters compared to individual treatments, suggesting a synergistic effect between the active compounds. A reduction in transepidermal water loss (TEWL), modulation of inflammatory cytokine expression (IL-4, IL-13, TNF-α), and improvement in the SCORAD score were observed. These findings support the role of the cutaneous endocannabinoid system and the antioxidant aciona of quercetin as promising therapeutic targets for CAD management. Therefore, this research reinforces the potential of topical phytotherapeutic strategies as a viable alternative for the treatment of atopic dermatitis, with future perspectives in veterinary clinical practice.

COMMITTEE MEMBERS:
Interna - ANA LUCIA FIGUEIREDO PORTO
Interna - ***.719.364-** - MARIA TEREZA CARTAXO MUNIZ - UPE
Interno - ***.993.114-** - ROMERO MARCOS PEDROSA BRANDÃO COSTA - UPE