Banca de QUALIFICAÇÃO: NATHÁLIA ANDREZZA CARVALHO DE SOUZA

CHEMICAL STUDY AND EVALUATION OF THE BIOLOGICAL POTENTIAL OF Mimosa tenuiflora PEELS FOR

 DRUG DEVELOPMENT.

Jurema preta; extraction optimization; DMT; analytical techniques

Medicinal plants have several chemical compounds belonging to the class of secondary metabolites, and among them the chemical class of alkaloids. The species Mimosa tenuiflora, popularly known as "Jurema-preta" has active indole alkaloids with several pharmacological properties described in the literature, among them, analgesic, anti-inflammatory, stimulating and depressant activity of the central nervous system. The period in which the plant sample is collected can influence the content of chemical constituents present due to seasonal variations. In this sense, the objective of this work will be the chemical study and evaluation of the biological potential of Mimosa tenuiflora shells for drug development. The development of a drug based on natural compounds requires effective quality control from spectroscopic techniques for proper identification. For this it is important the development and validation of analytical methods for identification and quantification by High Performance Liquid Chromatography, quality control of the formulation according to the Brazilian pharmacopoeia, toxicological and pharmacological tests for advances in these data obtained in therapeutic and clinical. As an expected result this project will serve as a subsidy for the development of a drug based on compounds of the bark of Mimosa tenuiflora.