Banca de QUALIFICAÇÃO: ANNELIESE GONÇALVES COSTA MARINHO

COMPOSITION OF PHARMACEUTICAL FORMULATION AND ITS PRODUCTION PROCESS, FROM AN OIL/WATER 

NANOEMULSION, CONTAINING CORN OIL RICH IN CANNABIDIOL, INHALED FOR THE THERAPY OF SEVERE

 ACUTE RESPIRATORY SYNDROME.

Cannabinoids. Pain. Inflammation

In the past decade, rigorous scientific methods have been employed to investigate the effects of cannabinoids on nociceptive and anti-inflammatory neurotransmission. It has been observed that these substances significantly reduce signaling in specific neural pathways responsible for transmitting messages related to pain and inflammation. These effects arise from the suppression of nociceptive neurons in the spinal cord and thalamus, irrespective of any actions on the motor system or on sensory neurons transmitting messages unrelated to pain. Sites of analgesia with cannabinoid receptors have been identified in spinal, supraspinal, and peripheral regions. The discovery of endocannabinoids has raised the question of their natural role in pain relief. Multiple lines of evidence indicate that endocannabinoids naturally play a role in pain suppression. Although it is now clear that cannabinoids suppress nociceptive neurotransmission, further research is still needed to establish the clinical utility of these compounds. Regarding inflammation of the respiratory system, investigation into new methods of treatment and prevention is necessary. Cannabinoids are compounds that warrant special attention for studies, as they exert their biological effects through their type 1 (CB1) and/or type 2 (CB2) receptors.