Banca de DEFESA: JACKSON DE MENEZES BARBOSA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JACKSON DE MENEZES BARBOSA
DATE: 29/07/2022
TIME: 08:00
LOCAL: google meet
TITLE:

OBTAINING, CHARACTERIZATION AND EVALUATION OF ANTINOCICEPTIVE ACTIVITY OF INCLUSION COMPLEX

CONTAINING MONOTERPENE CAMPHOR IN B-CYCLODEXTRIN.

KEY WORDS:

Monoterpenes, Camphor, β-Cyclodextrin, Nociception, Orofacial Pain

PAGES: 108
BIG AREA: Outra
AREA: Multidisciplinar
SUBÁREA: Biotecnologia
SUMMARY:

Natural products have emerged as an alternative in the search for new drugs to treat pain. The incorporation of cyclodextrins (CDs) in pharmaceutical systems is a promising strategy for the production of new drugs, increasing the solubility, stability and bioavailability of drugs. Thus, the antinociceptive activity of camphor and its inclusion complex in β-cyclodextrin (CF-Bc) were evaluated. The camphor complex in B-cyclodextrin was prepared from physical mixtures of CF and Bc components, which were later lyophilized. The physicochemical characterization of the complex was performed by Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) and Molecular Docking.For the antinociceptive evaluation, mice were treated with doses of 200 and 400 mg/kg, v.o of CF and Bc, in different pharmacological models: acetic acid-induced abdominal contortions, formalin test and heat nociception (hot plate). In order to elucidate the mechanism of action, the antinociceptive activity of CF, some pharmacological antagonists were used, through the formalin test. Camphor and CF-βc showed an antinociceptive effect, involving opioid, serotoninergic (5HT3), ATP-sensitive potassium channels (KATP) and muscarinic receptors. We also investigated the orofacial antinociceptive activity of CF and CF-βc, induced by formalin, capsaicin and glutamate, in which the orofacial antinociceptive effect was evidenced, possibly involving the opioid and TRPV1 receptors.The evaluation by the rota rod and open field tests did not show any alteration in motor control. Thus, the results show the therapeutic potential of camphor for obtaining pharmacological products in the treatment of pain.

BANKING MEMBERS:
Presidente - 030.165.124-83 - JACKSON ROBERTO GUEDES DA SILVA ALMEIDA - UNIVASF
Interno - 803.979.560-53 - MATEUS MATIUZZI DA COSTA - UFSM
Interna - 786.067.303-78 - MARIA HELENA TAVARES DE MATOS - UECE
Externa à Instituição - JULLYANA DE SOUZA SIQUEIRA QUINTANS
Externo à Instituição - JOSÉ LAMARTINE SOARES SOBRINHO