Banca de QUALIFICAÇÃO: GABRIELA REIS XAVIER

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : GABRIELA REIS XAVIER
DATE: 10/12/2025
TIME: 09:00
LOCAL: meet.google.com/afo-htyj-qeu
TITLE:

In vitro activity of CBD-rich oil and H4CBD against bacterial isolates from the uterus of mares

KEY WORDS:

Equine endometritis; Antimicrobial resistance; Biofilm; Cannabinoids; Alternative therapies

PAGES: 39
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Reprodução Animal
SPECIALTY: Fisiopatologia da Reprodução Animal
SUMMARY:

Infectious endometritis is one of the leading causes of infertility in mares, characterized by inflammation of the endometrium resulting from the presence of bacterial or fungal agents. The current limited response of conventional therapies to these pathogens reflects the rise of antimicrobial resistance and reinforces the need for new therapeutic approaches. Traditional treatment relies on the use of antimicrobials and supportive therapies, but the recurrence of cases has driven the investigation of alternatives such as cannabidiol (CBD) and tetrahydrocannabinol (H4CBD). The present study aimed to evaluate the main agents involved in equine infectious endometritis, their antimicrobial resistance profiles, biofilm forming capacity, and to test the in vitro potential of H4CBD and CBD against the isolates. Forty-eight uterine samples were collected from mares with a history of subfertility and diagnosed with endometritis. Microbiological isolation, antimicrobial susceptibility testing, and in vitro assays for biofilm formation were performed. The isolated microorganisms exhibited different resistance profiles to the antimicrobials tested, with notable cases of multidrug resistance. In addition, biofilm-forming capacity was observed in 47.92% of the strains, suggesting an additional challenge to conventional treatment. The findings reinforce the importance of investigating alternative therapeutic approaches, including CBD and H4CBD, which exhibit anti-inflammatory, immunomodulatory, and potential antimicrobial properties described in experimental studies. The partial results indicate that antimicrobial resistance and biofilm formation are relevant factors in the persistence of infectious equine endometritis. Thus, the use of H4CBD and CBD emerges as a promising strategy, requiring controlled in vitro assays.

COMMITTEE MEMBERS:
Presidente - GUSTAVO FERRER CARNEIRO
Externa à Instituição - AMANDA LINS BISPO MONTEIRO - UFRPE
Externo à Instituição - ANDRE DE SOUZA SANTOS - UFRPE
Externo à Instituição - 1884884 - ANDRE DE SOUZA MELO - UFRPE