Banca de DEFESA: AMANDA RODRIGUES DOS SANTOS MAGNABOSCO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : AMANDA RODRIGUES DOS SANTOS MAGNABOSCO
DATE: 26/03/2025
TIME: 13:00
LOCAL: Online via Google Meet
TITLE:

Development of nanoemulsions based on vegetable oils and evaluation of their efficiency against fetal alcohol syndrome (FAS) using zebrafish (Danio rerio) embryos and larvae as an animal model

KEY WORDS:

Zebrafish, Prenatal Alcohol Exposure, Embryotoxicity, Teratogenic Effects

PAGES: 118
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUMMARY:

Fetal Alcohol Syndrome (FAS) is a severe condition affecting between 2% and 5% of children worldwide due to alcohol consumption during pregnancy. This syndrome, the most severe form of Fetal Alcohol Spectrum Disorders (FASD), is characterized by physical, cognitive, and behavioral deficiencies, making it one of the leading preventable causes of intellectual disability. The high prevalence of FAS is exacerbated by a lack of awareness among pregnant women about the risks of alcohol and the absence of an effective treatment. Even with the cessation of alcohol consumption during pregnancy, the effects can be irreversible, and diagnosis typically occurs late in prenatal care. For studying the effects of FAS, Danio rerio (zebrafish) proves to be an excellent animal model, offering significant advantages compared to other models. This fish has a high genetic similarity to humans and a large progeny with transparent eggs, embryos, and larvae, which facilitates the observation of embryonic development with the aid of an optical microscope. The use of zebrafish as a model for FAS is well-established and capable of reproducing effects observed in human patients. Nanotechnological systems, such as nanoemulsions, have the potential to serve as efficient carriers of bioactive molecules to reverse the effects of FAS during fetal development. Nanoemulsions are known for their ability to efficiently carry bioactive molecules. Developing a nanotechnological system composed of the mentioned substances may provide a specific treatment for FAS with restorative and anti-inflammatory properties. Given that FAS is a syndrome of high prevalence, the application of nanotechnology can not only provide important information for the population and pregnant women but also represent an innovative and cost-effective approach for the prevention and treatment of the syndrome, leveraging the compounds used in its formulation.

COMMITTEE MEMBERS:
Presidente - PABYTON GONCALVES CADENA
Interno - PAULO ROBERTO ELEUTERIO DE SOUZA
Externo ao Programa - 1929164 - FRANCISCO DE ASSIS LEITE SOUZA - UFRPEExterna à Instituição - MARIA DO CARMO DE BARROS PIMENTEL - UFPE
Externo à Instituição - YURI MATEUS LIMA DE ALBUQUERQUE - UPE