Banca de DEFESA: ISABELA CRISTINA BANDEIRA FRAGA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ISABELA CRISTINA BANDEIRA FRAGA
DATE: 29/02/2024
TIME: 14:30
LOCAL: Google Meet
TITLE:

Investigation of the potential of curcumin as an immunotherapy agent against experimental salmonellosis

KEY WORDS:

Curcumin, herbal medicines, salmonellosis.

PAGES: 62
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Medicina Veterinária Preventiva
SPECIALTY: Doenças Infecciosas de Animais
SUMMARY:

Among the bacteria that cause food infections, species of the genus Salmonella stand out, capable of causing gastroenteritis and systemic disease that can lead to death, creating a constant demand for new therapeutic approaches. Curcumin has been reported for its medicinal properties, being a promising herbal medicine. In this research, its potential was examined in a model of experimental salmonellosis caused by S. enterica serotype Typhimurium, which affects several animal species of agricultural importance and humans. Initially, the direct antimicrobial effect of curcumin against S. Typhimurium in vitro was evaluated. Subsequently, tests involving animals were approved by the UFRPE Ethics Committee on the Use of Animals. Mouse peritoneal macrophages were obtained from the peritoneal cavity, infected with S. Typhimurium and treated with curcumin. Additionally, Swiss mice were infected intraperitoneally with a bacterial suspension and treated with curcumin at dosages of 1 and 10 mg/kg. As a control, infected animals treated with 10 mg/kg of gentamicin and untreated animals (PBS group) were used. After 72 hours, the animals were euthanized and the spleen, liver, peritoneal fluid and blood were collected. Next, the number of Colony Forming Units (CFU) in these samples and the total and differential leukocyte counts in the peritoneal fluid and blood were quantified.

COMMITTEE MEMBERS:
Externo à Instituição - JEFFERSON SOARES DE OLIVEIRA
Presidente - JOSE VITOR MOREIRA LIMA FILHO
Externa à Instituição - ROSSANA DE AGUIAR CORDEIRO
Interno - VALDEMIRO AMARO DA SILVA JUNIOR