Banca de DEFESA: LÍLIA JOSEFA VIDAL ROMÃO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LÍLIA JOSEFA VIDAL ROMÃO
DATE: 21/02/2024
TIME: 09:00
LOCAL: Sala de seminários do CEGOE
TITLE:

Use of mesenchymal stem cells in the therapy of cauda equina syndrome in dogs: a clinical study.

KEY WORDS:

cauda equina syndrome
mesenchymal stem cells
cell therapy
treatment

PAGES: 100
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

The cauda equina syndrome is an acquired or congenital alteration, where the nerve fibers located in the lumbosacral vertebral canal are compressed, leading to an injury with intense inflammation and consequently to neurological and nociceptive changes in the patient. The treatment for this disease is based on medication, surgery and/or physical therapy aimed at removing the underlying cause and reducing inflammation. However, recovery is not always fast or practical, considering the cause and severity of the injury, management and established therapy. In addition, there are cases of patients who also have associations with osteoarticular diseases, making the recovery process even more complex, such as hip dysplasia or intervertebral disc disease. Some alternative treatments have been studied to improve the prognosis of cases, such as stem cells, which have shown to be very promising regarding the functions they play in the recovery of joint injuries, soft tissues and even neurological tissues such as the medulla itself, for example. acquired conditions such as trauma or congenital conditions, such as juvenile hip dysplasia. In view of this, the present work had as its main objective to use Mesenchymal Stem Cells, obtained from adipose tissue of dogs, in patients with cauda equina syndrome, diagnosed by imaging tests and who present evident clinical symptoms of the disease. All the mechanisms that these cells can play in adult tissue are still not completely clear, but with the knowledge already acquired and with the results of the animals in the present work, cell therapy can be a tool as an adjuvant to conventional therapy or, depending on the cases, as an alternative in the treatment of Cauda-Equina Syndrome in dogs.

COMMITTEE MEMBERS:
Presidente - ANISIO FRANCISCO SOARES
Externo ao Programa - 2279588 - MARCELO WEINSTEIN TEIXEIRA - UFRPEExterna à Instituição - ANA AUGUSTA PAGNANO DERUSSI
Externo à Instituição - MARCELO JORGE CAVALCANTE DE SÁ - UFCG