Banca de DEFESA: EVA LUANA ALMEIDA DA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : EVA LUANA ALMEIDA DA SILVA
DATE: 30/06/2022
TIME: 09:00
LOCAL: Plataforma Google Meet
TITLE:

Effect of low frequency magnetic field on cortical electrical activity of rats after induction of status epilepticus

KEY WORDS:

EEG, power spectrum, DFA, epilepsy,MF, EMF

PAGES: 77
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

Today's society constantly uses numerous electrical resources in their daily lives.
When the electric current is set in motion, a magnetic field is generated around the
current, when it comes to common electrical wiring the corresponding Electromagnetic
Field (EMF) has an extremely low frequency of up to 60 Hz. The literature presents
numerous studies dedicated to discovering the influences of exposure to EMF in
healthy individuals or in the face of some disorder. However, there are contradictions
between the real effects of this exposure, there is no consensus as to the cause,
damage to health, possibilities in the treatment of diseases or if it does not cause any
influence to organisms. And, data linking EMF exposure up to 60 SHz on brain
electrical activity are scarce. Epilepsy is the most common neurological disease in the
world, and cortical electrical dysfunction makes the epileptic individual sensitive to
seizures in several aspects, including the environment. In this way, would the epilepsy
patient exposed to EMF be more likely to trigger changes in their cortical electrical
dynamics? If so, do such changes cause harm or benefit to the patient? In the present
work, we sought to verify the effects of exposure to EMF at 60 Hz on the parameters
of cortical electrical activity before and after an animal model of status epilepticus in
adult male rats. The electrocorticogram (ECoG) was used to record the electrical brain
activity of the animals. The ECoG was analyzed by mathematical methods: Spectral
Density (SD), Detrended Fluctuation Analysis (DFA). Eighteen 90-day-old Wistar rats
were recorded before and after pilocarpine induction of status epilepticus. After the
first record, the animals were divided into (G1 before and G2 before), then one group
received only the drug (G1 after) and the other group received the drug and underwent
CM (G2 after). The second record was obtained 24 hours after pilocarpine
administration and compared to that obtained before status epilepticus induction. The
DFA of the ECoG segment showed no significant difference in any of the groups. DE
showed a difference between G1 before and after G1 only in the delta wave. While the
DFA of alpha, delta and theta waves showed significant differences between G1 before
and after G1. This study suggests that 24-hour exposure to MC with an intensity of 1
mT and a frequency of 60 Hz was able to attenuate the effects of status epilepticus on
brain electrical activity.

BANKING MEMBERS:
Presidente - 1130289 - ROMILDO DE ALBUQUERQUE NOGUEIRA
Interno - 2199130 - EMMANUEL VIANA PONTUAL
Externo à Instituição - ISVÂNIA MARIA SERAFIM DA SILVA LOPES - UFPE
Externo à Instituição - JULIANA OLIVEIRA DE CARVALHO - UFPI
Externo à Instituição - EDBHERGUE VENTURA LOLA COSTA