Banca de QUALIFICAÇÃO: PAULO HENRIQUE SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : PAULO HENRIQUE SILVA
DATE: 19/12/2024
TIME: 14:30
LOCAL: Google Meeting
TITLE:

EVALUATION OF THE POSSIBLE PROTECTIVE EFFECTS OF Enterococcus faecium 137V AGAINST METASTASES FROM INDUCED COLORECTAL CANCER

KEY WORDS:

metastasis, probiotics, lung

PAGES: 45
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Patologia Animal
SPECIALTY: Anatomia Patologia Animal
SUMMARY:

Colorectal cancer is one of the most common types of malignant tumors in both men and women. This type of cancer begins in the final portion of the intestine, with adenocarcinoma being the most common. Furthermore, more than half of the patients diagnosed with this disease present metastasis, in which case the tumor spreads to other tissues, preferably to organs such as the lungs and liver. Probiotic bacteria, which confer health benefits to individuals when administered in adequate amounts, have shown good results in mitigating pre-neoplastic inflammation. Furthermore, lactic acid bacteria of the species Enterococcus faecium have shown, through both in vitro and in vivo studies, the potential for modulating the immune system, as well as for reducing intestinal inflammation induced by chemical agents. Thus, the main objective of this project is to evaluate the potential of EF137v in the development of metastasis in organs such as the lungs, analyzing histological and histochemical parameters. Based on the studies developed, EF137v is effective in mitigating neoplastic inflammation in lung tissue, demonstrating attenuation of immune cell infiltration and preserving healthy lung architecture. However, the observation of adverse effects should be the objective of future evaluation, so that the use of this probiotic as an antitumor agent becomes an alternative.

COMMITTEE MEMBERS:
Presidente - MARIA TACIANA HOLANDA CAVALCANTI
Interna - RAQUEL PEDROSA BEZERRA
Externo à Instituição - LEANDRO FRAGOSO LINS