Banca de DEFESA: ROBERTA CAVALCANTI FISCHER PACHECO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ROBERTA CAVALCANTI FISCHER PACHECO
DATE: 31/07/2024
TIME: 14:30
LOCAL: Google Meeting
TITLE:

Evaluation of Lactobacillus rhamnosus as an adjunct in the treatment of atopic dermatitis in dogs (Cannis lupus familial)

KEY WORDS:

Probiotic, dermatopathy, adjuvant

PAGES: 82
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SUMMARY:

Probiotics, including L. rhamnosus, have been increasingly used in recent decades due to their contribution to the health and well-being of humans and animals. Several studies corroborate the effectiveness of probiotics in the treatment of allergic pathologies and skin inflammations. , especially atopic dermatitis (AD). The specific mechanisms of the immunomodulatory effect of probiotics in AD are not fully understood, studies report a close correlation between the intestinal microbiota and several factors associated with the pathophysiology of this disease, such as immunity and inflammation. Experiments carried out with mice using the probiotic L. rhamnosus, achieved clinical improvement in symptoms and prevention of the development of AD through the inhibition of inflammatory cytokines. With a multifactorial etiology, the pathogenesis of canine atopic dermatitis (CAD) is complex, it is an itchy skin disease and one of the most common skin diseases in dogs. It refers to allergic and inflammatory dermatopathy, genetically predisposed and resulting from an interaction between environmental and genetic factors, mediated by the immune system. CAD has no cure and clinical management is based on controlling the condition. Several methods have been proposed to improve and control the clinical signs of CAD, the use of anti-inflammatory and anti-pruridogenic medications, including topical/systemic glucocorticoids, cyclosporine and oclacitinib are the main therapeutic option, however, there are limitations in treatment as prolonged use or high doses of these medications has been associated with some adverse effects, therefore, there is a need for alternative treatments. Scientific studies show that probiotics, considered one of the adjuvant treatments, can be effective in treating this dermatopathy. In veterinary medicine, there are few reports on the use of probiotics in CAD, however, in recent years studies have been carried out involving the complementary effects of lactobacilli in this dermatopathy, demonstrating their therapeutic benefits in its management. Therefore, the objective of this study was to evaluate the probiotic Lactobacillus rhamnosus as an adjuvant in the treatment of atopic dermatitis (AD) in dogs.

COMMITTEE MEMBERS:
Presidente - MARIA TACIANA HOLANDA CAVALCANTI
Interna - KEILA APARECIDA MOREIRA
Interna - RAQUEL PEDROSA BEZERRA
Externo à Instituição - THIAGO PAJEÚ NASCIMENTO - UFPI