Banca de DEFESA: MATHEUS CANDIDO FEITOSA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MATHEUS CANDIDO FEITOSA
DATE: 21/02/2024
TIME: 14:00
LOCAL: Sala de seminários do CEGOE
TITLE:

USE OF CELL THERAPY USING MESENCHYMAL STEM CELLS IN THE TREATMENT OF CORNEAL ULCERS IN AN EXPERIMENTAL MODEL: CLINICAL, OPHTHALMOLOGICAL AND HISTOLOGICAL EVALUATION

KEY WORDS:

Ophthalmology, Treatment, Dogs, Clinical signs.

PAGES: 100
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Studies using mesenchymal stem cells (MSC) in veterinary ophthalmology demonstrate a reduction in the early inflammatory reaction of local corneal cells and innate immunity cells through paracrine mechanisms, in addition to benefits such as reduced ocular discharge, conjunctival hyperemia and demonstrate that when there is its use in the acute phase of trauma, there is greater local angiogenesis, less chance of opacity, in addition to better and faster healing of the corneal lesion, in addition to presenting lower and significant levels of formation of tumor necrosis factor alpha (TNFα) , group of cytokines capable of causing cell death. Regenerative medicine using cell therapy brings new opportunities for treatments in veterinary medicine and ophthalmology, thinking about patients and improving the standard of quality of life of those affected by diseases, bringing possibilities little applied in veterinary therapy, which when compared to the enormous casuistry of corneal injury, resulting in the urgency to observe it in a better applied way. After administration of 0.5x106 cells/mL into the subconjunctival sac of the eye with ulcer in the experimental models, with the first group (G1 – N=8) applied 1 hour after injury, the second group (G2 – N=8), applied cells 24 hours after injury and control groups, containing 8 animals for group G1, 8 animals for group G2 and 8 animals for comparison in a general control group, totaling 40 animals. A reduction in ulcers was observed within 48 hours in all animals that received stem cell application (16 animals), regardless of the time of injury, with 1 hour of MSC application or 24 hours of cell application. In addition to the reduction of ulcerative lesions, it was noted macroscopically that there was no additional process to the injury or recovery process, such as: conjunctival discharge, opacity, neovascularization, blepharospasm or pigmentation, throughout the entire evaluation process.

COMMITTEE MEMBERS:
Presidente - ANISIO FRANCISCO SOARES
Externo ao Programa - 385059 - FABRICIO BEZERRA DE SA - UFRPEExterno ao Programa - 2279588 - MARCELO WEINSTEIN TEIXEIRA - UFRPEExterna à Instituição - ANA AUGUSTA PAGNANO DERUSSI