Banca de DEFESA: DANIELLA SILVA BEZERRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DANIELLA SILVA BEZERRA
DATE: 27/02/2026
TIME: 14:00
LOCAL: Auditório do Departamento de Biologia da UFRPE-Sede
TITLE:

Occurrence and Environmental Risk Assessment of Antibiotics in the Capibaribe River Basin

KEY WORDS:

Ciprofloxacin residues, Azithromycin residues, Clarithromycin residues, Emerging micropollutants, Aquatic ecotoxicology.

PAGES: 52
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Toxicologia
SUMMARY:

Water is an essential resource for life and human development, but it is increasingly threatened by anthropogenic pressures, including the presence of emerging contaminants such as antibiotics. This research aimed to characterize the occurrence of azithromycin, clarithromycin, and ciprofloxacin in the Capibaribe River basin, assessing their potential risks to aquatic biota. Ten sampling points were monitored, from the river’s headwaters to the region near its mouth, covering stretches downstream of urban centers, during May, July, and August 2025, corresponding to the rainy season. Physicochemical, hydrobiological, and microbiological analyses were conducted in partnership with the State Environmental Agency of Pernambuco (CPRH), while sample extraction was performed at UFRPE and antibiotic determination at CETENE, using ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS). Water quality assessment revealed non-compliance with CONAMA Resolution No. 357/2005 for Class 2 rivers, with elevated levels of salinity, dissolved solids, turbidity, true color, soluble phosphorus, chlorophyll-a, and chlorides, as well as widespread detection of Escherichia coli, indicating strong influence of domestic, industrial, and agricultural effluents. Regarding antibiotics, most concentrations were below the quantification limit, except for ciprofloxacin at P5 in July, with 71.233 µg·L⁻¹, a value far higher than those reported in national and international studies. This site was characterized as a contamination hotspot, with a risk quotient (RQ) of 274, indicating a high ecological threat and potential for bacterial resistance selection. The results highlight that the Capibaribe River is undergoing critical degradation, posing risks to aquatic biodiversity and public health. This study represents the first systematic record of the spatial and seasonal distribution of these antibiotics in the basin, reinforcing the need for continuous monitoring and more effective environmental management policies.

COMMITTEE MEMBERS:
Presidente - GERALDO JORGE BARBOSA DE MOURA
Externa à Instituição - LUCIANA DE OLIVEIRA FRANCO
Externo à Instituição - MARCOS ANTONIO BARBOSA DE LIMA