Banca de QUALIFICAÇÃO: RANDERSON JOSÉ DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RANDERSON JOSÉ DA SILVA
DATE: 31/07/2024
TIME: 14:00
LOCAL: Google meeting - on-line
TITLE:

Evaluation of the therapeutic potential of phytocannabinoids in the intestinal microbiota and gut-brain axis of Wistar rats exposed to valproic acid during the gestational period (autism spectrum disorder).

KEY WORDS:

nanoemulsion; toxicity; behavior; oxidative stress.

PAGES: 67
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Patologia Animal
SPECIALTY: Anatomia Patologia Animal
SUMMARY:

Cannabis sativa is revolutionizing contemporary medicine due to its therapeutic potential, with proven efficacy in various clinical applications such as neurological diseases, chronic pain, and inflammations. Its main active compounds, THC and CBD, have anti-inflammatory, analgesic, anxiolytic, antidepressant, and neuroprotective properties. This study aims to evaluate the effects of administering an oil extract nanoemulsion of Cannabis sp. on the gastrointestinal tract of Wistar rats exposed to valproic acid during gestation, a model of autism spectrum disorder, characterized by deficits in social communication, stereotyped behaviors, cognitive deficits, and gastrointestinal problems due to intestinal hyperpermeability, among others. On the 13th day of gestation, the females received a single dose of sodium valproate (600 mg/kg). After 30 days of birth, the male pups were divided into two groups: one treated with 1.0% oil extract of Cannabis sp. in nanoemulsion and the other as a positive control. Negative control groups were also formed for comparison. During the treatment, tests were conducted to evaluate cognitive and motor functions. After 30 days, the animals were euthanized, and fragments of the gastrointestinal tract, liver, kidney, and brain were collected for histopathological, morphometric, histochemical, and oxidative stress analyses. The administration of Cannabis sp. compounds in nanoemulsion form can enhance the absorption and efficacy of phytocannabinoids, making it essential to evaluate their effects on hepatic metabolism, renal excretion, gastrointestinal system, and nervous system.

COMMITTEE MEMBERS:
Presidente - VALDEMIRO AMARO DA SILVA JUNIOR
Interna - TANIA MARIA SARMENTO DA SILVA
Externa à Instituição - FERNANDA CAROLINA RIBEIRO DIAS - UFTM