Banca de DEFESA: CARLOS ROBERTO CRUZ UBIRAJARA FILHO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CARLOS ROBERTO CRUZ UBIRAJARA FILHO
DATE: 23/02/2024
TIME: 14:00
LOCAL: https://meet.google.com/eea-kcec-mzb
TITLE:

Epidemiological aspects of zoonotic trypanosomatids in the Meridional Agreste region of Pernambuco, Northeastern Brazil

KEY WORDS:

Chagas disease. Epidemiology. Leishmaniasis. One Health. Zoonoses.

PAGES: 135
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Medicina Veterinária Preventiva
SPECIALTY: Doenças Parasitárias de Animais
SUMMARY:

The Trypanosomatidae family comprises the prominent zoonotic representatives, the protozoa Trypanosoma cruzi and Leishmaniabelonging to the subgenera Leishmania and Viannia, etiological agents of American trypanosomiasis and leishmaniasis, respectively. These parasites are vector-borne, and among the diverse vertebrate hosts, Canis lupus familiaris holds significant epidemiological importance. The Northeast region of Brazil, located in a tropical area, is endemic to these parasitosis caused by the agents above. The Southern Agreste region has shown the presence of human and canine cases, vectors, and favorable environmental conditions for maintaining the epidemiological cycles. This research aimed to study the epidemiological aspects of zoonotic trypanosomatids in the Southern Agreste of Pernambuco, Northeast Brazil. Secondary data (2009–2019) regarding human leishmaniasis cases were obtained from the Notifiable Diseases Information System (NDIS) through the Pernambuco State Health Department, specifically from the V Regional Health Management (V RHM). CDC light traps were installed in five locations from September 2020 to August 2022 to capture sandflies. Geographical coordinates were recorded using remote sensing via the Global Positioning System (GPS) Garmin Etrex20. Blood samples were collected from dogs for serum extraction and anti-Leishmania and anti-T. cruzi antibody research. 116 (annual average of 10.5 ± 8.5) leishmaniasis cases were registered in the study area. Among these cases, 61 (annual average of 5.5 ± 5.5) were diagnosed as Visceral Leishmaniasis (VL) and 55 (annual average of 5 ± 4.3) as Cutaneous Leishmaniasis (CL). VL cases were recorded in 61.9% (13/21) of the locations, while CL cases were 42.8% (9/21). Most cases were predominantly reported in rural men, specifically for CL in the 30 to 59 years age range. A total of 168 sandfly specimens were captured over 24 months, all identified as Lutzomyia evandroi, with 61.9% (104/168) females and 38.1% (64/168) males, and a higher concentration of specimens from March to June. Out of 155 dog sera samples, a prevalence of 5.1% (8/168) was seropositive for T. cruzi, and 2.5% (4/155) of dogs was seropositive for L. infantum. These findings not only confirm the circulation of T. cruzi and Leishmania spp. among humans, dogs, and vectors but are crucial to understanding the epidemiological dynamics of these protozoan diseases in the studied area, enabling the formulation of new hypotheses and questions, serving as an alert to health authorities to direct surveillance actions to vulnerable areas, as well as adopting measures to mitigate risks.

COMMITTEE MEMBERS:
Presidente - RAFAEL ANTONIO DO NASCIMENTO RAMOS
Interna - GILCIA APARECIDA DE CARVALHO
Interno - LEUCIO CAMARA ALVES
Externa à Instituição - CARINA LUCENA MENDES MARQUES - UFRPE
Externa à Instituição - LUCIA OLIVEIRA DE MACEDO