Banca de DEFESA: JAIURTE GOMES MARTINS DA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JAIURTE GOMES MARTINS DA SILVA
DATE: 15/06/2023
TIME: 08:00
LOCAL: Recife
TITLE:

ANALYSIS OF HEALING OF CUTANEOUS WOUNDS IN DIABETIC RATS TREATED WITH BACTERIAL CELLULOSE ASSOCIATED OR NOT TO MELATONIN

KEY WORDS:

Biopolymers; Exopolysaccharides; Wound Healing; Melatonin; Rat

PAGES: 96
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUBÁREA: Histologia
SUMMARY:

Introduction: Skin wounds are difficult to heal in people with diabetes, as there is great vascular and tissue impairment. Many alternatives appear, aiming to reduce the time and effectiveness of healing, in a less expensive and more effective way. Bacterial cellulose dressings, with or without the addition of another molecule, appear as a choice. Melatonin is a hormone with also proven effects on wound healing. Objective: To describe the effects of melatonin associated with bacterial cellulose on the healing of skin wounds in diabetic rats. Methods: Wistar rats were used and, after wound induction, they were randomly divided into four groups. GC – Non-diabetic rats with skin lesions; GDCC - Diabetic rats with skin lesions and treated with a commercial healing agent; GDCB - Diabetic rats with skin lesions and treated with Bacterial Cellulose; GDMCB - Diabetic rats with skin lesions and treated with Melatonin and Bacterial Cellulose. The animals were accompanied during 3, 7 and 14 experimental days. The following were evaluated: Glycemic levels, histopathological and histochemical analyzes were performed, and the healing rate was quantified, morphometric analysis, C-reactive protein, Immunohistochemistry (IL-6, TNF-α, VEGF and PCNA) and collagen I and III. Results: The animals in the GDCB and GDMCB groups achieved better wound healing than the animals in the GC and GSCC groups according to the evaluated methods. Conclusion: Bacterial cellulose-based dressings associated with melatonin showed beneficial results in healing experimentally induced wounds in rats, favoring the healing process, decreasing healing time, increasing collagen production and regulating inflammatory cytokines.

COMMITTEE MEMBERS:
Presidente - ALVARO AGUIAR COELHO TEIXEIRA
Interno - EMMANUEL VIANA PONTUAL
Externa à Instituição - FERNANDA DAS CHAGAS ÂNGELO MENDES TENÓRIO
Externa à Instituição - GIRLIANE REGINA DA SILVA
Externa à Instituição - ISMAELA MARIA FERREIRA DE MELO