Sloths are mammals belonging to the order Pilosa, and they have been suffering from devastating anthropic actions. These animals have an arboreal habit and a diet based on leaves and shoots, which may contain toxic content in their composition, highlighting the importance of a better understanding of the organic systems, highlighting the hepatic activity in these animals. In this context, a morphological and vascular description of the liver was proposed, under different conditions and techniques, in order to collaborate with the literature, preservation and medical clinic of sloths. For this, 22 animals were used, 21 corpses from the CETAS Wild Animal Screening Center and one living in semi-captive conditions, from the Instituto Preguiça de Garganta Marrom, in the Dois Irmãos State Park, all of them belonging to the Bradypus variegatus species. Analyzes were performed on 16 animals in the Anatomy pavilion, aiming for the morphological description. Therefore, the specimens were fixed with 20% formaldehyde and preserved in 30% saline solution for further analysis, such as skeletopy, syntopy, histology and vascular description. In 13 of the 16 animals, the technique of injection of latex was performed, in order to obtain a reliable visualization of the vessels, where the latex, added with the red color and injected into the hepatic artery of four animals, highlighting the vascularization of the organ, as well as as it was injected into the hepatic portal vein of five animals in blue color, intending to visualize the portal venous system. Finally, the bile duct was cannulated in four animals with the same substance already described and in green color, until the bile ducts were filled. Subsequently, they were fixed in 20% formaldehyde and preserved in 30% saline solution for later dissection. In one animal, the vinylite technique was performed, where the vinyl was repaired and kept in a glass container for 48 hours. Then, yellow oil paint was added to the common bile duct, blue to the hepatic portal vein and red to the hepatic artery. The stained solution was injected into each vessel described above, then the organ was removed and placed in a container with water for 24 hours, soon after exposed to HCL (hydrochloric acid) solution for 5 days, then removed for analysis of the vessels. With regard to histopathology, liver fragments from four sloths were used, fixed in 10% buffered formaldehyde and subjected to the process and inclusion of paraffin, for sagittal sections of 4 um, then stained with hematoxylin-eosin and later analyzed. A tomography examination was performed in a healthy female in semi-captivity conditions. The animal was sedated and placed in the ventral decubitus position on the tomography scanner for the examination. Subsequently, the images were analyzed in order to obtain a faithful view of the organ in its natural position and location and liver conditions. The liver presented two faces, one convex towards the diaphragm (diaphragmatic face) and the other concave facing the abdominal organs (visceral face), with four main lobes; left lobe, right lobe, square lobe and caudate lobe with its caudate process, appearing in the cranial abdominal region of the right antimere, cranially between the 7th and 9th ribs and caudally between the 13th and 14th ribs, which varied between male and female. In the hepatic vascularization, it was observed that, when entering the organ, the hepatic artery divided into two branches, one right and the other left, which were subdivided emitting smaller-caliber branches to all the lobes found in the liver of the common sloth. In the bile ducts, hepatic duct resulted from the confluence of three branches that converged to form a common branch. According to the histopathological findings of the liver, necrotic foci were observed, which may be associated with some abnormality of the vascular supply, inflammatory processes which may be related to the defense of the organ in the fight against foreign agents, as well as dilatations in the sinusoids, and pathogen encapsulation. In the bile ducts, hepatic duct resulted from the confluence of three branches that converged to form a common branch. According to the histopathological findings of the liver, necrotic foci were observed, which may be associated with some abnormality of the vascular supply, inflammatory processes which may be related to the defense of the organ in the fight against foreign agents, as well as dilatations in the sinusoids, and pathogen encapsulation.