Banca de DEFESA: JOYCI TORRES DE PAULA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOYCI TORRES DE PAULA
DATE: 25/02/2022
TIME: 09:00
LOCAL: https://meet.jit.si/DefesaJoyci
TITLE:

Clinical staging of dogs with natural infection by Leishmania infantum and confronts of the serological tests profile in the evaluating of different clinical stages of canine visceral leishmaniasis

KEY WORDS:

Clinical classification; Diagnosis; Leishmania infantum, Canine Medicine

PAGES: 70
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Medicina Veterinária Preventiva
SPECIALTY: Doenças Parasitárias de Animais
SUMMARY:

Clinical staging can help to better understand the patient's prognosis and decision making in the treatment of dogs with Canine Visceral Leishmaniasis (CVL). Thus, the objective was to perform clinical staging of dogs with natural infection by Leishmania infantum and compare the profile of serological tests with the different stages of CVL. For that, domiciled dogs of both sexes and different ages were used, with a positive diagnosis for CVL through bone marrow biopsy. Clinical staging was performed by evaluating clinical signs, hematological and serum biochemical changes in addition to antibody titration. There were five stages considered: Stage 1 (no disease), Stage 2 (mild disease), Stage 3 (moderate disease), Stage 4 (severe disease), and Stage 5 (extremely severe disease). It was found that 73.7% (59/80) of the dogs had moderate disease, 19% (15/80) had mild disease, 6% (5/80) were in the stage of severe disease, and 1.3% (1/80) were in the stage of severe disease. 80) with a very serious illness. The level of antibodies showed a significant difference between these stages (p<0.05), but it was not a determinant for the classification of animals in the different stages of the disease. However, animals with high levels of Total Protein (>12g/dL) and azotemia were classified in the most severe stages of the disease, regardless of clinical signs and antibody profile. In correlating the levels of antibodies evaluated by different serological techniques, IFAT and ELISA, with the clinical signs, only in the IFAT was a statistical difference between the stages identified, but stage 3 was the one with the highest median titration. It is concluded that it is possible to perform the clinical staging of dogs naturally infected with L. infantum from a set of data, including clinical signs, clinical-pathological analyses, and serological tests, placing them in stages with different levels of severity. However, the lack of uniformity in serology makes its application in staging difficult.

BANKING MEMBERS:
Presidente - 384005 - LEUCIO CAMARA ALVES
Interno - 2292423 - RAFAEL ANTONIO DO NASCIMENTO RAMOS
Externa à Instituição - DANIELA DA SILVA PEREIRA CAMPINHO - UFRPE
Externa à Instituição - EDNA MICHELLY DE SA SANTOS - UFRPE
Externa à Instituição - RENATA PIMENTEL BANDEIRA DE MELO - UFRPE