Banca de DEFESA: ALEF DE MOURA PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ALEF DE MOURA PEREIRA
DATE: 27/02/2026
TIME: 14:00
LOCAL: Sala de Microscopia - DMFA
TITLE:

HEPATIC PATHOPHYSIOLOGICAL EFFECTS ON THE HEPATIC OF ADOLESCENT RATS TRAINED AND SUBJECTED TO OVERDOSES OF NANDROLONE DECANOATE AND SUSTANON

KEY WORDS:

Steroids; Metabolism; Liver; Inflammation

PAGES: 82
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUBÁREA: Histologia
SUMMARY:

Nandrolone decanoate and Sustanon stand out among the most commonly used anabolic steroids in the fitness environment, being administered in cycles and at supraphysiological doses to enhance muscle gains, thereby triggering damage mediated by oxidative stress and inflammatory pathways. The liver is one of the most affected organs, exhibiting progressive structural and functional damage that may evolve into fibrosis and compromise overall health. Thus, the aim of this study was to evaluate the effects resulting from supraphysiological and synergistic supplementation with two anabolic steroids in trained adolescent rats aged 40 days. The animals were divided into four groups: trained control rats (RT), rats treated with nandrolone (RTN), rats treated with Sustanon (RTS), and rats treated with nandrolone plus Sustanon (RTNS). Morphometric, histological, and histochemical parameters (Mallory’s trichrome staining), oxidative stress markers (TBARS, NADPH oxidase, GSH, SOD, and catalase), inflammatory cytokines (IL-1β and TNF-α), organosomatic indices, and biochemical markers of hepatic injury and metabolism were analyzed in the livers of the experimental groups. Animals treated with Sustanon exhibited centrilobular congestion, leukocyte infiltration, disorganization of hepatic cords and sinusoids, collagen deposition, and increased cytokine levels (TNF-α and IL-6) in liver tissue, as well as serum biochemical alterations (LDL, ALT, AST, HDL, and total cholesterol) and changes in oxidative stress markers (TBARS, NADPH oxidase, GSH, SOD, and catalase). The nandrolone group and the group receiving the combination of Sustanon plus nandrolone showed findings similar to those observed in the Sustanon group, differing mainly in the magnitude of the alterations and by the presence of multiguttular steatosis and hepatocellular ballooning, which were particularly intensified in the synergistic group. Therefore, this research aims to expand scientific knowledge regarding the effects and risks associated with the non-therapeutic use of androgenic substances, as well as to provide support for public awareness, healthcare professional practice, and the development of preventive measures and public policies aimed at reducing the harm related to this type of consumption.

COMMITTEE MEMBERS:
Presidente - ALVARO AGUIAR COELHO TEIXEIRA
Interno - ANISIO FRANCISCO SOARES
Externo à Instituição - LEUCIO DUARTE VIEIRA FILHO - UFPE