Banca de DEFESA: LUCAS NUNES SANTANA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LUCAS NUNES SANTANA
DATE: 22/10/2024
TIME: 09:00
LOCAL: Google Meet
TITLE:

Development of a phytotherapeutic formulation containing Cratylia argentea lectin (CFL) for the experimental treatment of listeriosis

KEY WORDS:

ConBr, Listeria monocytogenes, therapeutic adjuvants, immunomodulatory action.

PAGES: 110
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Medicina Veterinária Preventiva
SPECIALTY: Doenças Infecciosas de Animais
SUMMARY:

In the present study, the influence of the CFL lectin from Cratylia argentea was evaluated on: A) clearance of L. monocytogenes in the blood, peritoneal fluid, spleen, liver, brain and lung of infected mice; B) migration of leukocytes in the blood of infected animals; C) intracellular bacterial clearance in primary cultures of infected macrophages; D) in the prevention of histological damage from spleen, liver, brain and lung infection; E) in the gene expression of the cytokines TNF-α, IL-1β, IL-6, IL-10 and other inflammatory mediators; F) activation of T lymphocytes using flow cytometry; G) combined treatment with antibiotics of the infection in vivo.

COMMITTEE MEMBERS:
Presidente - JOSE VITOR MOREIRA LIMA FILHO
Interno - VALDEMIRO AMARO DA SILVA JUNIOR
Externa ao Programa - 2068698 - ANNA CAROLINA SOARES ALMEIDA - UFRPEExterna à Instituição - ANA DE FATIMA FONTENELE URANO CARVALHO - UFC
Externo à Instituição - JEFFERSON SOARES DE OLIVEIRA