Banca de DEFESA: LAURE RACHEL LARA MARIE BEZERRA BARBOSA DE ARAÚJO MOUTHUY

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LAURE RACHEL LARA MARIE BEZERRA BARBOSA DE ARAÚJO MOUTHUY
DATE: 27/09/2024
TIME: 14:30
LOCAL: AUDITÓRIO
TITLE:

DEVELOPMENT OF NANOEMULSION BASED ON THE ASSOCIATION OF ESSENTIAL OILS AND EVALUATION OF ITS STABILITY AND ACARICIDE EFFECT IN VITRO

KEY WORDS:

Dermacentor nitens; Vetiver; acaricide; nanoemulsion

PAGES: 111
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Medicina Veterinária Preventiva
SPECIALTY: Doenças Parasitárias de Animais
SUMMARY:

Ticks are the main vectors of pathogens in animals and humans, and
billions of dollars are spent annually to control them. The zoonotic potential
of the Dermacentor nitens vector mainly affects equids. Essential oils
individually, combined, as well as nanoformulations are a potent ecological,
economical, dose-reducing and less toxic alternative for non-target
organisms. In the literature, no reports of tick-killing essential oils
nanoemulsified in Dermacentor nitens were found, so the objective of this
dissertation was to develop a nanoemulsion based on the association of
essential oils and evaluate its stability and acaricide effect in vitro. A
selection with the essential oils of Clove (Syzygium aromaticum), Vetiver
(Chrysopogon zizanioides), Basil (Ocimum basilicum), Lemongrass
(Cymbopogon citratus), Laurel (Laurus nobilis) and Thyme (Thymus
vulgaris) was fulfilled to evaluate tick activity using the immersion test with
better efficacy in Dermacentor nitens teleogynes. The combination of the
best oils was evaluated by augmented Simplex-centroid mixture planning.
Then, the nanoemulsions of the best combination were produced with
cashew gum at high and low energy, characterized and evaluated their
stability and acaricide effect. The results obtained demonstrated that
Vetiver, Lemongrass and Basil showed tick-killing activity. However, no
synergy or antagonism was observed in the statistical analysis of binary and
tertiary mixtures. Being the only one with a product efficacy above 95%,
Vetiver was nanoemulsified. The low-energy nanoemulsion showed stability
and efficacy of 100%. This nanoemulsion could be a base for the
development of innovative formulations and their application in the
veterinary parasitology field. Therefore, more research is needed on the
possible optimizations of the nanoemulsion and the combined use of
essential oils, the effect of cashew gum on the tick, as well as on the
applicability in the field and on a large scale.

COMMITTEE MEMBERS:
Presidente - ANA LUCIA FIGUEIREDO PORTO
Externa à Instituição - JUANIZE MATIAS DA SILVA BATISTA - UFRPE
Interna - MARIA TACIANA HOLANDA CAVALCANTI