Banca de DEFESA: VICTOR FELIPE DA SILVA ARAÚJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VICTOR FELIPE DA SILVA ARAÚJO
DATE: 28/02/2023
TIME: 16:00
LOCAL: Online
TITLE:

Fractal analysis of fundus images of patients with different degrees of diabetic retinopathy with and without risk of maculopathy.

KEY WORDS:

Fractal geometry, diabetic retinopathy, macular edema, diabetes mellitus, retinographies

PAGES: 75
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

Diabetes Mellitus is among the main chronic diseases that have a high rate of morbidity and mortality, leading to a large government investment in the treatment of its complications. Diabetic retinopathy is the most common complication of diabetes mellitus that can lead to vision loss. This alteration arises with a microvascular complication generated by diabetes mellitus, which occurs due to hyperglycemia, thus resulting in structural and functional alterations of the retinal capillaries. The aim of this study was to investigate whether fractal geometry is capable of identifying changes in the retinal vascular network from fundus images of patients with different grades of diabetic retinopathy and also at risk for macular edema. Thus, the study was divided into two parts. The first part of the study, chapter 1 of this dissertation, included 90 fundus retinographies from the MESSIDOR database, in individuals without retinopathy and with different grades of diabetic retinopathy. Four groups were analyzed: one without retinopathy (n=23), and three others with grade one (n=20), grade two (n=20) and grade three (n=27) diabetic retinopathy. The degrees of retinopathy were classified according to the number of microaneurysms, number of hemorrhages and presence of neovascularization. The images were skeletonized and quantified by fractal methods: dimension of box count and information. The results of this work showed that the fractal methods employed were able to demonstrate that the different grades of diabetic retinopathy do not alter the structure of the vascular network. In chapter 2, 46 retinographies of patients with diabetic retinopathy classified into grades according to the number of microaneurysms, hemorrhages and the presence of neovascularization were selected: grade 2 and grade 3 with and without macular edema. The fractal dimension values and the number of bifurcations of the vascular networks of the retinas (whole and in the macular region) showed no statistical differences between the groups with grade 2 diabetic retinopathy without and with risk of macular edema, as well as between the groups with grade 3 retinopathy without and with risk of edema. The fractal dimension and the number of bifurcations did not reveal significant alterations in the architecture of the retinal vascular network in patients with retinopathy at risk of diabetic macular edema

COMMITTEE MEMBERS:
Presidente - ROMILDO DE ALBUQUERQUE NOGUEIRA
Interno - JOAQUIM EVENCIO NETO
Externo à Instituição - THIAGO DE SALAZAR E FERNANDES - UFPE