Banca de DEFESA: BRUNO JOSE DO NASCIMENTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BRUNO JOSE DO NASCIMENTO
DATE: 28/02/2023
TIME: 08:00
LOCAL: Recife-PE
TITLE:

Evaluation of the effect of melatonin administration on diabetic heart disease at the cellular, histochemical, immunohistochemical and biochemical levels

KEY WORDS:

antioxidant; hyperglycemia; anti-inflammatory; cytokines; cardiac injury markers

PAGES: 60
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUBÁREA: Histologia
SUMMARY:

he objective of this research was to analyze the effects of melatonin administration on the heart of rats induced to diabetes. Twenty albino males of the Wistar lineage, 70 days old, from the Vivarium of the Department of Animal Morphology and Physiology at UFRPE, were used, divided into the following groups: Control: rats without induced diabetes; Diabetic: rats induced to diabetes; Diabetic + insulin: induced diabetes and treated with insulin; Diabetic + melatonia: induced diabetes and treated with melatonin. All treatments lasted 30 days. Diabetes was induced by streptozotocin at a dose of 60 mg / kg ip, and melatonin at a dose of 10 mg / kg ip. Insulin was administered subcutaneously at a dose of 5 IU/day. In the histopathological analysis, diabetic and diabetic animals + insulin showed significant disorganization and vacuolation of cardiomyocytes with scores above 2 (moderate to extensive degeneration of cardiomyocytes with diffuse infiltration of inflammatory cells) and 1 (mild; degeneration of cardiomyocytes with discreet infiltration of inflammatory cells ), respectively. Morphometric analysis revealed that diabetic animals showed increased heart wall thickness, reduced lumen and higher lumen/wall thickness ratio. In addition, these animals showed greater marking for cardiac collagen, and high levels of total creatine kinase, creatine kinase MB, lactate dehydrogenase, Troponin, IL-6 and TNF-α. These effects were prevented by melatonin. Thus, we can conclude that melatonin has great potential in preventing the development of diabetic heart disease in rats.
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Painéis laterais

COMMITTEE MEMBERS:
Presidente - ALVARO AGUIAR COELHO TEIXEIRA
Interna - VALERIA WANDERLEY TEIXEIRA
Externo à Instituição - BRUNO MENDES TENORIO - UFPE