Banca de DEFESA: TALITA NAYARA BEZERRA LINS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : TALITA NAYARA BEZERRA LINS
DATE: 31/08/2022
TIME: 09:00
LOCAL: https://meet.google.com/qfi-gyoi-cqd
TITLE:

25-HYDROXYVITAMIN-D SERUM LEVELS IN DOGS WITH NATURAL Leishmania infantum infection (Nicollle, 1908)

KEY WORDS:

Canine visceral leishmaniasis, calcitriol, zoonosis

PAGES: 52
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Medicina Veterinária Preventiva
SPECIALTY: Doenças Parasitárias de Animais
SUMMARY:

Canine visceral leishmaniasis is a zoonosis, caused by protozoa of the genus Leishmania, transmitted by sandflies, and the domestic dog is its main urban reservoir in Brazil. In dogs, the TH2-mediated response will favor the production of antibodies by B lymphocytes, which may trigger the onset of clinical signs of the disease, such as: dermatitis, lymphadenopathy, joint problems, hyporexia, diarrhea, vomiting, fever, ophthalmological problems, in addition to systemic changes such as hepatomegaly and nephropathies. It is known that the role of vitamin D goes beyond the musculoskeletal system and its hypovitaminosis would be related to infectious diseases, chronic enteropathies, pancreatitis, neoplasms, polyneuritis and chronic kidney disease. Due to its role as a cofactor for reactions in B and T cells, catalyzing pro-inflammatory cytokines. This study aimed to analyze the serum levels of vitamin D relating the clinical manifestations presented by dogs naturally infected by Leishmania infantum. Sera from 43 animals were used, divided into two groups: Group 1, composed of 10 animals, screened through the immunochromatographic test, all of which were non-reactive. In Group 2, composed of 33 animals, in which the inclusion criteria were immunochromatographic reagent tests and parasitological examination of the bone marrow showing amastigote forms of Leishmania sp. For both groups, vitamin D levels were measured by the chemiluminescence method. As for vitamin D levels, among the Group 1 animals the serum levels varied between 20 ng/mL and 52.2 ng/mL and among the Group 2 animals the variation was between <20ng/mL and >50ng/mL, of which 39 .39% had hypovitaminosis with levels below 20ng/mL. The data observed in this study suggest that animals naturally infected with Leishmania sp. with vitamin D levels <20 ng/mL and 50 ng/mL there was a predominance of onychogryphosis, while in animals with levels >50ng/mL there was a predominance of desquamative dermatitis.

BANKING MEMBERS:
Presidente - 1680404 - GILCIA APARECIDA DE CARVALHO
Interno - 2292423 - RAFAEL ANTONIO DO NASCIMENTO RAMOS
Externa ao Programa - 2240345 - EDNA MICHELLY DE SA SANTOS - UFRPEExterno à Instituição - DANILLO DE SOUZA PIMENTEL