The objective of this study was to strengthen the surveillance of exogenous intoxications for the detection and prevention of intoxications by pesticides in the municipalities belonging to the V Regional Health Management (V GERES). A descriptive quantitative and qualitative epidemiological study was carried out. In the first stage, data from the Information System on Notifiable Diseases-SINAN and the Information System on Mortality-SIM, from 2008 to 2018 on exogenous intoxications, were analyzed. To describe the perception of health professionals about exogenous intoxications, a self-administered questionnaire was used, with questions about detection and notification of exogenous intoxications. Based on the questionnaires, training was carried out with health professionals on the subject. For the profile of the Agents for Combating Endemic Diseases-ACE, another self-applied questionnaire was used. As main results, 46.57% were male and 53.43% were female. The age group with the highest percentage and statistical significance was in young people aged 10 to 19 years. The most frequent toxic agent was drugs (35.12%), the main route of exposure was digestive (77.58%) and circumstances were suicide attempts (29.86%), 47% of exposures were acute-only . In the SINAN 44 registered cases that evolved to death and registered in the SIM there are 68 deaths due to intoxications, in the same period. Of the 142 health professionals, 74.64% claimed to know the exogenous intoxication notification form, 95.07% reported that it is mandatory notification and 98.59% recognized the importance of filling in the occupation variable. A total of 705 health professionals from different categories participated in training on exogenous intoxications. 137 professionals participated in the ACE’s questionnaires, 62.05% were male, 99.27% used pesticides/chemicals in their work activities, 64.24% were aged between 21 and 40 years, 40.87% with more than 10 years of work, 83.22% said they used Personal Protective Equipment and 75.18% underwent examination for cholinesterase dosage. For surveillance and prevention of any disease or illness, it is necessary, in addition to passive surveillance actions by monitoring notification data, to establish partnerships with Primary Care and proactively act in the territories, since the data presented in this study support planning in health and reaffirm the need for action and monitoring in a oriented and integrated health care network, through intersectoral actions between Health Surveillance and Primary Care.