Banca de DEFESA: ANTHONY MARCOS GOMES DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANTHONY MARCOS GOMES DOS SANTOS
DATE: 28/02/2022
TIME: 09:00
LOCAL: Recife-PE
TITLE:

The effect of melatonin on the expression of pro-inflammatory cytokines in the liver and testes of rats induced to chronic alcoholism

KEY WORDS:

Alcoholism; testes, melatonin, oxidative stress

PAGES: 51
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUBÁREA: Histologia
SUMMARY:

Alcoholism is a multifactorial chronic disease caused by the continuous consumption of alcohol. This condition affects people of different social classes, age and gender, causing social, moral, psychological, economic and physiological consequences, increasing morbidity and mortality worldwide. The physiological changes caused by alcoholism have their pathogenesis mediated by oxidative stress. These molecules promote damage to various structures such as proteins and lipids and also promote the mobilization of pro-inflammatory cytokines, which can lead to cell death, necrosis and loss or decline of organ function. Antioxidant treatment has shown protective and reversive effects caused by alcoholism in different organs. The present study aimed to analyze the effects of exogenous melatonin administration on some morphometric, hormonal and immunohistochemical aspects in the testes of young rats induced by chronic alcoholism. Thirty 40-day-old Wistar rats were used, divided into the following groups: I: (control): rats without alcohol treatment; II: rats submitted to chronic consumption of 25% hydroalcoholic solution; III: rats submitted to chronic consumption of 25% hydroalcoholic solution and treated simultaneously with melatonin. The animals in groups II and III received a 25% hydroalcoholic solution for a period of 60 days, after 4 weeks of adaptation with increasing concentrations of alcohol (5, 10, 15 and 20%). Melatonin was administered intraperitoneally at a dose of 10 mg/kg from day 30 to day 60 of the experiment. Hormone dosages revealed a significant reduction in serum testosterone in the animals of the alcohol group, when compared to the other experimental groups. The histopathological analysis of the testes of the animals of the alcohol group showed disorganization of the seminiferous epithelium, acquiring an aspect of tissue degeneration, while the melatonin alcohol group showed intact seminiferous epithelium with well-defined cellular elements. There was a reduction in body weight, testes and organosomatic index in animals that received alcohol compared to control and those treated with melatonin.

BANKING MEMBERS:
Presidente - 384942 - ALVARO AGUIAR COELHO TEIXEIRA
Interna - 2308550 - VALERIA WANDERLEY TEIXEIRA
Externa à Instituição - ISMAELA MARIA FERREIRA DE MELO