Banca de QUALIFICAÇÃO: ANTHÉOGENES MENEZES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANTHÉOGENES MENEZES
DATE: 25/02/2025
TIME: 14:00
LOCAL: Auditório do Departamento de Química
TITLE:

PLATINUM(2+)-BASED METALLODRUG CONTAINING AMINOALCOOL AS LINK: SYNTHESIS, CHARACTERIZATION AND STUDY OF ANTITUMORAL ACTIVITY

KEY WORDS:

cancer, platinum metallodrugs, anticancer activity.

PAGES: 74
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

Studies of platinum-based complexes to combat cancer have been carried out frequently through various scientific studies and research. Cancer can be described as the unregulated multiplication of genetically modified cells. A defining characteristic of cancer is the rapid creation of abnormal cells that grow beyond their usual limits and can invade adjacent parts of the body and spread to other organs. Since a drug with anticancer activity can prevent the multiplication of abnormal cells and block events that favor the evolution of the tumor, platinum-based complexes offer positive results. This research was proposed to synthesize, characterize, and study the cytotoxicity and acute toxicity activity of a platinum(2+) complex with an amino alcohol ligand as a drug candidate. A platinum complex was synthesized using aminoethylethanolamine (AEEA) as a ligand, obtaining a yield of 95.7%. This compound was then characterized by the ultraviolet-visible absorption spectroscopy method, verifying its formation, highlighting a band at 413nm, and monitoring its stability for 48 hours. The FTIR spectroscopy showed decreased wavenumbers and a signal around 496 cm-1, confirming the Pt-N bond. Nuclear magnetic resonance analyses were carried out on 1H and 13C where the spectra showed the expected chemical shifts. Analysis of the mass spectrometry results corroborates the formation of the complex. In vitro tests (cytotoxicity) with the cell lines F929 (mouse fibroblast), NCI-H292 (human mucoepidermoid lung carcinoma), HL-60 (acute promyelocytic leukemia), and HCT-116 (colorectal carcinoma) with a reduction in cell viability of 37% for some cells. The acute toxicity tests of the AMS complex allowed us to characterize the complex as category 2.

COMMITTEE MEMBERS:
Externo à Instituição - EDUARDO CARVALHO LIRA
Interno - JOAO RUFINO DE FREITAS FILHO
Externa ao Programa - ***.096.204-** - LIDIANE MACEDO ALVES DE LIMA - UFRPE
Presidente - WAGNER EDUARDO DA SILVA