Banca de QUALIFICAÇÃO: PEDRO RAMOS DE SOUZA NETO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : PEDRO RAMOS DE SOUZA NETO
DATE: 31/01/2024
TIME: 09:30
LOCAL: online
TITLE:

SYNTHESIS OF O-GLYCOPYRANOSIDES WITH
POTENTIAL ANTIVIRAL ACTIVITY AGAINST
ZIKA, DENGUE AND CHIKUNGUNYA VIRUS

KEY WORDS:

O-glycosides, 2-iodo-deoxy-O-glucosides, DIDMH.

PAGES: 186
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

This work aimed to synthesize and characterize novel O-glycosides and 2-iodo-deoxy-O-glycosides from D-glycals with various primary alcohols. Initially, compound BPSE 11 promoted the protection of tri-O-acetyl-D-glucal 12a to provide PSE-D-glucal 13a in 77% yield. This was followed by acetylation of the compound PSE- D-glucal 13a in 80% yield and oxidation in 82% yield. To obtain the O-glycosides, PSE-D-glycals 13a-b was used with the epoxidizing agents MCPBA and Oxone® in the presence of acetone in a basic medium to give compounds 14, 15a-b, 16a-b and 17a-b in good yields. In parallel, tri-Oacetyl-D-galactal 12b was prepared in 52% yield. Subsequently, the series of 2- iodo-deoxy-O-glycosides were prepared using the D-glycals 12a-b and 13a using the iodine reagent DIDMH at reflux and microwave irradiation, obtaining excellent yields

COMMITTEE MEMBERS:
Presidente - RONALDO NASCIMENTO DE OLIVEIRA
Interno - JOAO RUFINO DE FREITAS FILHO
Interno - ***.451.424-** - JULIANO CARLO RUFINO DE FREITAS - UFCG
Externo ao Programa - 2002989 - ANDRE AUGUSTO PIMENTEL LIESEN NASCIMENTO - UFRPEExterna à Instituição - BRUNA MARTINS GUIMARÃES - UFRPE
Externa à Instituição - SHALOM PORTO DE OLIVEIRA ASSIS - UNICAP