Banca de DEFESA: IVAN MARTINS BARRETO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : IVAN MARTINS BARRETO
DATE: 31/07/2025
TIME: 09:30
LOCAL: video conferência
TITLE:

SYNTHESIS OF NEW N-HETEROCYCLIC DERIVATIVES CATALYSED BY
TRANSITION METALS (COPPER/PALLADIUM) AND STUDY OF THEIR
ANTIVIRAL BIOLOGICAL PROFILE

 

KEY WORDS:

cycloaddition, click reaction, asymmetric synthesis,
diastereoselective arylation, 1,2,3-triazole, arylglycines

 

PAGES: 280
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Heterocyclic compounds are molecules that contain a heteroatom in their
structure, forming 5- or 6-membered rings. Generally, this heteroatom can be
nitrogen, oxygen or sulphur. These compounds are of great importance in
synthetic and medicinal organic chemistry, accounting for approximately 75% of
the published works. Among the vast class of heterocyclic compounds, those that
contain nitrogen in their structure deserve special mention, also known as
nitrogenated heterocycles or N-heterocycles. The presence of the nitrogen
heteroatom enables these compounds to interact easily with macromolecules,
such as proteins, enzymes and DNA, imparting them with diverse biological
properties, as documented in the literature, including antimicrobial, antiviral,
anticancer and anti-inflammatory activities. In the design and development of new
biologically active compounds, it is common to incorporate one or more
heterocycles, which provides these compounds with advantages, such as the
potential to expand the spectrum of biological activity. In the first chapter, we
carried out the copper-catalysed cycloaddition reaction to link phthalimide rings
with pyrimidine bases, conjugated to the isomers of 1,2,3-triazole 1,4-
disubstituted, containing 3 or 5 heterocyclic nuclei, with biological evaluation of
some compounds against SARS-CoV-2. In the second chapter, we performed the
diastereoselective arylation of the bis-lactim ether with a wide range of aryl
chlorides via palladium-catalysed asymmetric synthesis, also obtaining arylated
glycine. As a result, new N-heterocyclic compounds were obtained via two distinct
routes, with promising biological potential.

 

COMMITTEE MEMBERS:
Presidente - RONALDO NASCIMENTO DE OLIVEIRA
Interno - JOAO RUFINO DE FREITAS FILHO
Interno - CELSO DE AMORIM CAMARA
Externa à Instituição - WILLYENNE MARILIA DANTAS - Fiocruz - PE
Externo à Instituição - LINDOMAR JOSE PENA - Fiocruz - PE
Externo à Instituição - CLAYTON QUEIROZ ALVES - UEFS
Externa à Instituição - SHALOM PORTO DE OLIVEIRA ASSIS - UNICAP