Banca de DEFESA: MARIA HELENA PIRES SOUZA DE ANDRADE

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARIA HELENA PIRES SOUZA DE ANDRADE
DATE: 20/02/2025
TIME: 08:00
LOCAL: Auditório do Departamento de Química
TITLE:

SYNTHESIS, CHARACTERIZATION AND STUDY OF THE ANTITUMORAL ACTIVITY OF NEW RUTHENIUM(3+) COMPLEXES ANALOGUES AND CONJUGATED TO 2,3-UNSATURATED O-GLYCOSIDE

KEY WORDS:

Cancer, 2,3-unsaturated O-glycosides, ruthenium(3+) prodrugs.

PAGES: 127
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

Cancer is one of the deadliest diseases in the world, mainly due to chemotherapy treatment, which has low selectivity and high toxicity involved. Thus, the study of new compounds that present fewer side effects associated with their chemotherapeutic use is necessary, and in this context, ruthenium(3+) compounds have stood out. By combining these metal ions with ligands of low toxicity, antitumor activity, and biocompatibility, such as glycosides, an overexpression of associated effects of an antineoplastic nature is expected, but with under expression of toxicity. The aim of this work is to develop ruthenium (3+) complexes containing 2,3-unsaturated O-glycosides and analogues as ligands that show high antitumor activity and low side effects. To this end, an unprecedented 2,3-unsaturated O-glycoside was synthesized from Tri-O-Acetyl-D-glycal, which was used as the ligand for the complex coded as [Ru(glyco)2(H2O)2], where glyco is the glycoside containing malic acid as an aglycone. By way of comparison, the complex containing the malate ion as a ligand was synthesized, which was coded as Na[Ru(MA)₂(H₂O)₂], where MA = malate ion. The complexes and their precursors were characterized using spectroscopic techniques and mass spectrometry. The infrared spectroscopy results showed the presence of OH, C=O and CO functional groups in the free ligands and in the complexes in characteristic regions. The peaks referring to the CO and C=O stretching vibrations of the complexes were shifted to lower wavenumbers when compared to the same peaks of the free ligands, suggesting coordination to the metal ion. In addition, the spectrum of the complexes showed bands at 764 cm^-1 characteristics of Ru-O stretching. The ¹H and ¹³C NMR spectra of the tri-O-acetyl-D-glycal and the O-glycoside showed characteristic signals, which helped in the structural elucidation of the compounds. From the electronic absorption spectroscopy of the complexes, it was possible to observe changes in the electronic profile in relation to the free and coordinated ligand, which suggests the formation of the ruthenium-ligand coordinative bond. Mass spectrometry confirmed the minimum formula of the O-glucoside and the synthesized Na[Ru(MA)₂(H₂O)₂] complex. Thus, with the confirmation of the formation of the complexes, it is possible to begin the study of antitumor activity.

COMMITTEE MEMBERS:
Externa à Instituição - CARINE ÉMILE MENEZES LAGRANGE
Interno - ***.826.764-** - FAUSTHON FRED DA SILVA - UFPB
Presidente - MONICA FREIRE BELIAN
Externa à Instituição - TERESINHA GONÇALVES DA SILVA - UFPE
Interno - WAGNER EDUARDO DA SILVA