Banca de QUALIFICAÇÃO: FABRÍCIA APARECIDA MARQUES DE SOUZA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : FABRÍCIA APARECIDA MARQUES DE SOUZA
DATE: 29/08/2024
TIME: 14:00
LOCAL: Departamento de Química
TITLE:

SYNTHESIS, CHARACTERIZATION AND INSECTICIDAL ACTIVITY OF A SERIES OF ETHYL 3-(ARYL)-1,2,4-OXADIAZOLE-5-CARBOXYLATE.

KEY WORDS:

 Keywords: 1,2,4-oxadiazole, Plutella xylostella, new insecticides.

PAGES: 95
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Plutella xylostella, known as the diamondback moth, is an insect pest that affects several cruciferous vegetable crops and is responsible for economic losses estimated at billions of dollars annually spent on pest control and crop losses. With the indiscriminate use of broadspectrum insecticides, P. xylostella has developed cross-resistance to the main active ingredients commercially available as a form of natural protection, in addition to harming natural enemies and the environment. This scenario has contributed to the search for the environmentally friendly development of new active molecules that can mitigate this resistance and control the pest. The heterocycle 1,2,4-oxadiazole is a promising compound with numerous known biological activities, including insecticidal activity against pests. Knowing this, new 1,2,4-oxadiazoles will be developed from a sequence of steps aimed at obtaining the respective synthetic intermediates to obtain the desired compounds. The first step consisted of the preparation of aryl-amidoximes (Ph, p-NO2, p-Cl, p-Br, m-toluene, p-pyridinyl, and mpyridinyl) from aryl-nitriles (Ph, p-NO2, p-Cl, p-Br, m-toluene, p-pyridinyl, and m-pyridinyl), with yields reaching 90%. The respective amidoximes were then reacted with the ethyl chloroxoacetate ester to obtain 1,2,4-oxadiazoles in 80% yields. The third step consisted of the esterification reaction of ferulic acid in 98% yield. To date, intermediates for the target compounds have been synthesized in 90% yields, confirming that the methodological strategies addressed, which aim to obtain the target compounds through cleaner, more efficient, and faster routes, can be an excellent way to obtain the final compounds. 

COMMITTEE MEMBERS:
Presidente - JOAO RUFINO DE FREITAS FILHO
Interno - CLECIO SOUSA RAMOS
Externo ao Programa - 3022573 - JUCLEITON JOSE RUFINO DE FREITAS - UFRPEExterna à Instituição - BRUNA MARTINS GUIMARÃES
Externo à Instituição - JONH ANDERSON MACÊDO SANTOS - IFPE
Externa à Instituição - LIDIANE MACEDO ALVES DE LIMA