Banca de DEFESA: LÍDIA MARIA BARBOSA DO NASCIMENTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LÍDIA MARIA BARBOSA DO NASCIMENTO
DATE: 28/02/2024
TIME: 14:00
LOCAL: Departamento de Química - Sala Auditório
TITLE:

NEROLIDOL DERIVATIVES AS AN ALTERNATIVE INSECTICIDE FOR THE CONTROL OF Tetranychus urticae

KEY WORDS:

(E)-nerolidol, Melaleuca leucadendra, acaricide.

PAGES: 86
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:

Several essential oils have insecticidal activity, such as M. leucadendra oil, which contains (E)-nerolidol as the main compound. This compound has several biological activities such as: antimicrobial, anti-inflammatory, insecticidal and acaricidal. As (E)-nerolidol can be obtained naturally through M.leucadendra oil and this compound already has acaricidal activity, changes in its structure can promote better enhancement of this activity. Some reactions already reported in the literature that promote greater toxicity to the molecule's mechanism of action were tested on the (E)-nerolidol molecule, such as hydrogenation, acetylation, silylation and also epoxidation reactions. The reactions showed expected yields and the compounds could be characterized. Compared to the acaricidal effect of the substrate (E)-nerolidol, the hydrogenated compound (E)-nerolidol derived from the hydrogenation reaction presented a greater toxic effect on the two-spotted mite. The compounds were also subjected to the acetylcholinesterase (AChE) enzyme inhibition test, which, when inhibited by insecticides, can cause the accumulation of acetylcholine in synapses, leading to fatal consequences such as muscle paralysis, coma and death of pests (MENOZZI, P, et al, 2004). However, semi-synthetic compounds that do not inhibit AChE can be advantageous in the use of insecticides, as they do not cause harm to humans. The ones that showed the best results were (E)-nerolidol/Silylated and Acetylated/epoxidized, compared to the positive control Donezepil hydrochloride.

COMMITTEE MEMBERS:
Presidente - MARCILIO MARTINS DE MORAES
Interno - CLAUDIO AUGUSTO GOMES DA CAMARA
Interno - JOAO RUFINO DE FREITAS FILHO
Externo à Instituição - MARCILIO WAGNER FONTES SILVA