Banca de DEFESA: DANIELLE DIAS NEVES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : DANIELLE DIAS NEVES
DATE: 11/07/2023
TIME: 08:00
LOCAL: Auditório do Departamento de Química
TITLE:

DEVELOPMENT OF BORON CHELATES APPLIED IN NEUTRON CAPTURE THERAPY

KEY WORDS:

Cancer, BNCT, B-10, acute toxicity.

PAGES: 82
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

In this work, the compound levan-boron was synthesized as a new candidate for boron neutron capture therapy. The compound was characterized by spectroscopy in the infrared region showing bands in the regions of 1349 cm^-1 (vB-O-C) and 1128 cm^-1 (vBO4), electronic absorption spectroscopy, and nuclear magnetic resonance of ¹H, ¹³C and ¹¹B. After confirmation of its chemical structure, levan-boron solutions were irradiated with a thermal neutron beam in a reactor containing sources of americium-beryllium (AmBe) for periods of 19, 27 and 30 days, then, emission spectrometry analyzes were carried out (ICP-OES) to determine boron concentrations after ¹⁰B(n,α) ⁷Li nuclear reaction and observe ¹⁰B→⁷Li conversion rates. Cytotoxicity tests were carried out against Vero and MCF-7 cell lines and acute toxicity (OECD 423 Protocol). The results of these tests showed a percentage of cell viability between 70- 88% and 72-83%, respectively. The boron compound presented toxicological classification in category 5 in acute toxicity, which is very promising since it can proceed to irradiation tests in tumor cells and in vivo using animal experimentation.

COMMITTEE MEMBERS:
Interna - ***.823.784-** - BEATE SAEGESSER SANTOS - UFPE
Interno - JOAO RUFINO DE FREITAS FILHO
Presidente - MONICA FREIRE BELIAN
Externo ao Programa - 2994285 - RAMOM RACHIDE NUNES - nullExterna à Instituição - TERESINHA GONÇALVES DA SILVA - UFPE