Banca de DEFESA: DRIELLY EMANOELE TOMÉ BARROS DE OLIVEIRA
Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.STUDENT : DRIELLY EMANOELE TOMÉ BARROS DE OLIVEIRA
DATE: 27/02/2023
TIME: 14:00
LOCAL: Departamento de Química da UFRPE - Sala de seminários
TITLE:
SYNTHESIS OF NEW MOLECULES DERIVED FROM PRODUCTS NATURAL PRODUCTS WITH POTENTIAL FOR NEW DRUGS WITH ACTION ANTIMICROBIAL
KEY WORDS:
Piper caldense, 3-geranyl-geranyl-4-hydroxybenzoic acid, 1,2,4-oxadiazoles.
PAGES: 115
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:
The discovery of new antimicrobial compounds is imminent and a public health
problem, considering the notable increase in pathologies associated with
microorganisms such as fungi, viruses and bacteria, as well as the growing
emergence of microorganisms resistant to commercially available antibiotics.
There is no doubt that the natural product has been considered an excellent
source of new molecules as a prototype in the discovery of new drugs. Inserted
in this context, this work was directed to synthesize compounds derived from
natural products and evaluate their antimicrobial potential. Three 3-geranyl-
geranyl-4-hydroxybenzoic acid derivatives containing 1,2,4-oxadiazole ring and
an epoxy derivative were obtained. The acid was isolated from the
hydroalcoholic extract of Piper caldense roots in a 2% yield. The three
oxadiazoles were obtained by microwave irradiation, with yields ranging from
13%-33% and reaction time of 15-75min. Additionally, 3 synthetic derivatives of
retinoic acid were obtained, two derivatives containing the 1,2,4-oxadiazole ring
with yields of 7% and 27% and reaction times of 90 and 120 min. The structural
elucidations of the synthetic derivatives were determined based on the
interpretation of data from their respective IR, 1H and 13C NMR spectra.
COMMITTEE MEMBERS:
Presidente - CLECIO SOUSA RAMOS
Interno - JOAO RUFINO DE FREITAS FILHO
Interno - MARCILIO MARTINS DE MORAES
Externo ao Programa - 3022573 - JUCLEITON JOSE RUFINO DE FREITAS - UFRPEExterna à Instituição - GISELLE BARBOSA BEZERRA
Externa à Instituição - QUEILA PATRÍCIA DA SILVA BARBOSA FREITAS