Banca de DEFESA: SOKÈ GNINLOMÈ CÉDRIL HOUNKONNOU

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : SOKÈ GNINLOMÈ CÉDRIL HOUNKONNOU
DATE: 07/02/2025
TIME: 08:30
LOCAL: VideoConferência, Link: https://meet.google.com/hbs-ytyg-gtg
TITLE:

USE OF ELECTROCHEMOTHERAPY AS AN ADJUVANT IN THE EXCISION OF CUTANEOUS MAST CELL TUMORS IN DOGS

KEY WORDS:

Cancer; Oncology; Therapy; Neoplastic cells.

PAGES: 65
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SUMMARY:

Mast cell tumors are the most common skin tumors in dogs, being defined as a disordered proliferation of mast cells. The aim of this study was to evaluate the use of electrochemotherapy as an adjuvant in the treatment of cutaneous mast cell tumors in dogs. In total, 20 patients of different races were selected and monitored and whose average age was 8.25 years. The cytology examination with results suggestive of mast cell tumor was considered essential for the inclusion of patients in this study. After classifying patients according to the stage of the oncological disease, the therapeutic protocol established in this study consisted of surgical excision of the tumor and electrochemotherapy as adjuvant treatment. Electroporation was performed using the VetCP125 device, with a needle electrode, with the drug used for the technique being bleomycin at a dose of 15 IU/m2, intravenously. the following parameters were evaluated on the 7th, 15th and 45th day after the procedure: presence of secretion, necrosis, dehiscence and signs of tumor recurrence. As a result, a gradual reduction in the presence of secretion and necrosis was observed throughout the postoperative period; point dehiscence was observed in all patients who presented necrosis; 3 of the patients showed macroscopic signs of recurrence within 60 days; the histopathological examination showed that 70% of patients had low-grade mast cell tumors versus 30% high-grade mast cell tumors. it was concluded that the surgical removal of mast cell tumors associated with electrochemotherapy is an effective modality of treatment for this neoplasia, as it allows to avoid major mutilations, preserve important structures in addition to providing quality of life for the affected patient.

COMMITTEE MEMBERS:
Presidente - JOAQUIM EVENCIO NETO
Externa ao Programa - 2309518 - LILIAN SABRINA SILVESTRE DE ANDRADE - UFRPEExterno à Instituição - ROBÉRIO SILVEIRA DE SIQUEIRA FILHO - UFRPE