Banca de DEFESA: SAULO ROMERO FELIX GONCALVES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : SAULO ROMERO FELIX GONCALVES
DATE: 30/08/2024
TIME: 09:30
LOCAL: Google Meet: https://meet.google.com/xxm-ktnf-kaq
TITLE:

Epidemiological, Histomorphological, and Immunohistochemical Aspects of Canine Lymphomas in Northeastern Brazil (2012-2022)

KEY WORDS:

Dog, histopathology, immunohistochemistry, hematopoietic neoplasm, Northeast Brazil, WHO

PAGES: 83
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Patologia Animal
SPECIALTY: Anatomia Patologia Animal
SUMMARY:

Lymphoma is the most common malignant hematopoietic neoplasm affecting dogs. In veterinary medicine, there are few studies demonstrating the occurrence of the disease in Brazilian regions, especially in the Northeast. Therefore, considering the scarce studies on canine non-Hodgkin lymphoma (NHL) in Brazil, this work aimed to survey cases of canine non-Hodgkin lymphoma in Northeastern Brazil from 2012 to 2022, focusing on epidemiological, histomorphological, and immunophenotypic aspects. The survey resulted in the development of two studies. For the first study, titled “Canine Lymphoma in Northeastern Brazil: Epidemiological, Histomorphological, and Immunophenotypic Aspects,” 149 samples with a previous diagnosis of canine lymphoma were selected. The analyzed samples came from eight states in Northeastern Brazil (Alagoas, Bahia, Ceará, Paraíba, Pernambuco, Piauí, Rio Grande do Norte, and Sergipe). The average age of the affected animals was 8.38 years, with 55.03% (82/149) being males and 40.26% (60/149) females; of these, 30.87% (46/149) were mixed-breed dogs and 10.07% (15/149) were Poodles. Regarding the evaluated tissues, 34.23% (51/149) corresponded to lymph nodes, 30.87% (46/149) to skin, and 26.17% (39/149) to the spleen. Based on histomorphological and immunophenotypic results, 39.60% (59/149) were B-cell lymphomas, with Diffuse Large B-Cell Lymphoma (DLBCL) (45.76%; 27/59) and Splenic Marginal Zone Lymphoma (SMZL) (32.20%; 19/59) being the most observed, and 38.26% (57/149) were T-cell lymphomas, with Non-Epitheliotropic Cutaneous Lymphomas (43.85%; 25/57) and Epitheliotropic Lymphomas (17.54%; 10/57) being the most frequent. Non-neoplastic lymphoproliferative disorders were found in 6.04% (9/149). In the second study, titled “Intravascular Large T-Cell Lymphoma – Report of Two Cases,” the aim was to report the anatomical and immunohistochemical aspects of two dogs diagnosed with Intravascular Large T-Cell Lymphoma. For this, two dogs were necropsied: an Akita, male, 4 years old, and a Rhodesian Ridgeback, female, 10 years old. Both presented neurological clinical signs characterized by ataxia, seizures, and difficulty walking. Macroscopically, hepatomegaly, splenomegaly, and necrotizing encephalitis were observed. Microscopically, a predominance of large intravascular neoplastic lymphocytes was noted, with positive immunohistochemical staining for CD3 and negative for CD20, concluding that both cases were Intravascular Large T-Cell Lymphoma. The epidemiological and immunophenotypic profile of canine non-Hodgkin lymphoma cases in Northeastern Brazil does not differ from other profiles published in the country and worldwide. The increase in cutaneous lymphomas may signal some interference from edaphoclimatic aspects that may occur in our region, reinforcing the need for studies that consider environmental factors. The construction of a capillarized network of information on neoplasms occurring in Northeastern Brazil, such as lymphoma, would be of fundamental importance, allowing the monitoring of development indices and biological behavior, as already exists in human medicine.

COMMITTEE MEMBERS:
Presidente - ANDREA ALICE DA FONSECA OLIVEIRA
Externa à Instituição - LORENA GABRIELA ROCHA RIBEIRO - UFS
Externa à Instituição - MARCIA BERSANE ARAUJO DE MEDEIROS TORRES
Externa à Instituição - RAQUEL ANNES FAGUNDES SILVA
Externa à Instituição - TELMA DE SOUSA LIMA - UECE