Banca de DEFESA: LEANDRO LAMARTINE LOPES ROCHA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LEANDRO LAMARTINE LOPES ROCHA
DATE: 27/06/2024
TIME: 08:00
LOCAL: https://meet.google.com/kdz-arah-mot
TITLE:

Characterization of mammary papillomas in goats raised in the Northeast region of Brazil

KEY WORDS:

risk factors, mammary neoplasms, hyperplasia, bovine papillomavirus, small ruminant.

PAGES: 124
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

The present study aimed to characterize papillomatosis in dairy goats raised in the Northeast region of Brazil. A total of 58 dairy goat farms were visited, where an investigative questionnaire was applied, and animals from the herds were examined for lesions compatible with papillomatosis. In total, 1885 goats of different breeds, ages, and genders from thirteen municipalities in RN, PB, and PE were examined. Twenty-one goats (1.11%) with characteristic papillomatosis lesions were identified on 14 properties. Those with lesions underwent tissue collection using a dermatological punch (stored in formalin for histopathological analysis) and crust removal (frozen for molecular diagnosis). However, only 20 animals were macroscopically and microscopically examined. The majority, 76.1% (16/21), were of the Saanen breed. All observed lesions were on the udder (base, body, and teat), with 45% (9/20) in two areas (body and teat or base and body) and 35% (7/20) in only one area (body or teat). The characteristics of the papillomas found were: 25% (5/20) atypical, 25% (5/20) pedunculated, 15% (3/20) typical, 15% (3/20) atypical sessile, 15% (3/20) filamentous, and 5% (1/20) mixed (filamentous + pedunculated). Regarding lesion intensity, mild, intense, and moderate grades predominated at 65% (13/20), 30% (6/20), and 5% (1/20), respectively. The most common color observed was brown (80% or 16/20), followed by gray and skin color (10% or 2/20 each). Notably, 20% (4/20) of the goats presented exuberant neoplastic formations. Histopathological examinations demonstrated keratinization in all samples, with 50% (10/20) showing high intensity (+++), 30% (6/20) mild intensity, and 20% (4/20) moderate intensity. In the statistical analyses, the final multivariable model identified significant risk factors: lack of shade in the pen (PR=4.636), failure to isolate sick animals (PR=5.942), and needle reuse (PR=7.185). Another significant variable was that all goats were female adults, yielding a final model with a sample size of n = 1089. Additionally, lactating adult females were found to be another risk factor (PR=2.807). Finally, four animals underwent molecular examinations, revealing the presence of BPV-2 and two purported new types of BPV (putative new type - BAPV-5 and putative new - BPV-7), as well as co-infection with BPV-5 and BPV-13 in the same sample.

COMMITTEE MEMBERS:
Presidente - HUBER RIZZO
Externa à Instituição - PRISCILLA FAJARDO VALENTE PEREIRA - UEL
Externo à Instituição - GLAUCO JOSÉ NOGUEIRA DE GALIZA - UFCG
Externo à Instituição - MÁRIO FELIPE ALVAREZ BALARO - UFF
Externa à Instituição - TATIANE RODRIGUES DA SILVA - UFCG