Banca de DEFESA: JAIANNE KEITT ALVES DE MELO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JAIANNE KEITT ALVES DE MELO
DATE: 29/02/2024
TIME: 09:00
LOCAL: https://meet.google.com/nrq-gxgu-yxu
TITLE:

Detection of secondary metabolites and evaluation of the toxicity of Palicourea ssp in Artemia salina and goats

KEY WORDS:

Toxic plants, sudden death, Artemia salina, secondary metabolites, ruminants

PAGES: 54
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Patologia Animal
SPECIALTY: Anatomia Patologia Animal
SUMMARY:

Plants undergo vital biosynthesis processes that involve production, storage and decomposition of organic substances, including secondary metabolites. The objective is to identify the classes of secondary metabolites present in Palicourea hoffmannseggiana, P. capitata, P. barbiflora and P. colorata, evaluate the bioactivity in Artemia salina and the acute toxicity in goats. Specimens of Palicourea spp. were collected, identified and ethanolic and aqueous extracts were produced. Toxicity was evaluated through bioassay with Artemia salina and in experimental poisoning in goats. The phytochemical study revealed the presence of flavanones, catechins, steroids, saponins, alkaloids and coumarins. P. barbiflora was the only plant that showed high toxicity at all concentrations of the ethanolic extract. The species P.capitata (leaf) and P. colorata (leaf) showed toxicity at concentrations of 1.0 and 0.1 mg\mL. The ethanolic extract of P. hoffmannseggiana, P. colorata (seed) and P. aeneofusca were considered non-toxic against Artemia salina. In analyzes with aqueous extract, all species of Palicourea spp. demonstrate high toxicity, with the exception of P. barbiflora (leaves), classified as non-toxic. High Performance Liquid Chromatography (LC-MS) did not detect MFA in the Palicourea spp. species analyzed, and the acute poisoning experiment in goats was negative for sudden death due to the presence of MFA. The results obtained demonstrate evidence that species of the genus Palicourea have high cytotoxic potential, although not associated with the presence of MFA. The considerable toxicity presented by Palicourea spp. demonstrates the need to carry out more studies that support the results found, with the aim of analyzing more parameters that corroborate the results found.

COMMITTEE MEMBERS:
Presidente - FABIO DE SOUZA MENDONCA
Interna - ***.154.657-** - CARLA LOPES DE MENDONCA - UFRPE
Externa à Instituição - GLIERE SILMARA LEITE SOARES
Externo à Instituição - LUIZ CARLOS FONTES BAPTISTA FILHO
Externa à Instituição - TACIANA RABELO RAMALHO RAMOS