Banca de DEFESA: FABIANA OLIVEIRA COSTA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : FABIANA OLIVEIRA COSTA
DATE: 24/02/2023
TIME: 16:00
LOCAL: UFRPE - remota
TITLE:

·      Influence of supplementation with L-glutamine and/or chelated selenium on physiological and antioxidant mechanisms in elderly dogs

KEY WORDS:

catabolism, oxidative stress, geriatrics, immunonutrition, sarcopenia

PAGES: 113
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Aging is a complex genetic and physiological process, which implies the progressive regression of organic functions, resulting from endogenous and exogenous factors. The accumulation of toxic actions caused by reactive oxygen species, inadequate diet, lack of physical activity, limited environment and even negative emotional behavior further favors this decline. Decreased bioavailability of nutrients impairs metabolic homeostasis. Nutrition is a strong ally to minimize the impact of this phase of life. Supplementation with amino acids such as Glutamine (Gln) which participates in protein synthesis, immune system, digestive system, antioxidant, among other functions, is of great value in geriatrics. The inclusion of micronutrients such as selenium (Se) which is involved in different metabolic processes, acting on the endocrine, immune, anti-oxidation system and even on the muscular system, has added even more benefits. This study aimed to supplement elderly dogs with L-glutamine at 0.33g/Kg, with chelated selenium at 0.006mg/Kg, or with a combination of both, to assess the influence of supplements on physiological and oxidative stress biomarkers.  Thirty clinically healthy elderly dogs, ≥ 10 years, were randomly assigned to 3 groups: glutamine [GLN]; selenium chelate [SE]; glutamine and selenium chelate [GLN+SE], receiving supplementation for 30 days. The collections took place before the beginning of the supplements (T0), serving as a control parameter, and after 15 (T15) and 30 (T30) days. Data were collected through a questionnaire on lifestyle, body condition (ECC, IMCC), and blood samples for analysis of biomarkers of the hematological profile (RBC, WBC, PLT) of energy metabolism (TG, CHO, HDL, LDL, VLDL), protein metabolism (GLN, GLU, ALB, TP), kidney function (UR, CR, UA), liver function (ALT, ALKP, GGT), oxidative stress (GPx and TBARS). The works developed for this thesis showed that the elderly dogs in this study had a sedentary pattern, anxious behavior, reduced lean mass, decreased serum levels of Gln in T0 and hyperlipidemia. Supplements containing Gln were able to increase Gln levels (P<0.05) and the combination Gln+Se was able to modulate oxidative stress in the proposed context (P<0.05). There was also, an improvement on the lipid profile in the [GLN+SE] group (P<0.05) and the proposed dosages in all supplementation did not alter biomarkers of renal and hepatic function.

COMMITTEE MEMBERS:
Interno - HELIO CORDEIRO MANSO FILHO
Externa ao Programa - 1786867 - DANIELA MARIA BASTOS DE SOUZA - UFRPEExterna à Instituição - WALESKA FERREIRA DANTAS
Externa à Instituição - ELISAMA DE CASTRO TORRES
Externa à Instituição - MYCHELLE BRUNA DA SILVA BARROS