Banca de DEFESA: TAILE KATIELE SOUZA DE JESUS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : TAILE KATIELE SOUZA DE JESUS
DATE: 25/02/2022
TIME: 14:00
LOCAL: Google Meet (https://meet.google.com/zej-omqq-jrf)
TITLE:

Intoxicação acidental por organofosforados em ovinos

KEY WORDS:

Dichlorvos, liver enzymes, late neuropathy, sheep, small ruminants.

PAGES: 72
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Toxicologia Animal
SUMMARY:

Organophosphate compounds constitute a group of chemical substances widely used in agricultural activities as insecticides for crops and antiparasitic for animals. Despite their beneficial action, the inappropriate use of these products can lead to deleterious effects, and eventually outbreaks of intoxication in domestic animals. Due to the impact of these compounds on the health of animals and humans, through direct or indirect exposure to the chemical agent, the objective was to report an outbreak of accidental intoxication by organophosphates in sheep from the state of Pernambuco, Brazil. The death of forty crossbred Santa Inês sheep, aged between three and 36 months, which presented late intoxication after accidental exposure to the insecticide dichlorvos, is described. The clinical signs observed were bradycardia, bronchoconstriction, diarrhea, salivation, nasal secretion, apathy, prostration, motor incoordination, pressure of the head against objects, neck stiffness, paresis, flaccid paralysis of the limbs, permanent recumbency and death. After the onset of clinical symptoms, the deaths occurred within an interval of forty days. For diagnosis, four animals were necropsied, blood samples were collected for measurements of hepatic and renal metabolites, and toxicological analysis was performed. Steatohepatitis was observed in the serum biochemistry, pneumonia, congestion of the leptomeninges vessels, edema and congestion of the pulmonary, pericardial and cerebral convolutions in the anatomopathological analyses; hepatic macrosteatosis, hepatic and renal congestion, and central nervous system edema with white matter demyelination on histological analyses; and positivity for organophosphorus substances in pooled samples, analyzed by thin layer chromatography. It is concluded that the clinical epidemiological findings associated with biochemical, pathological and toxicological analyzes are consistent with the clinical course of an induced late neurotoxicity associated with severe hepatic steatosis after exposure to organophosphate compounds.

BANKING MEMBERS:
Presidente - 2073025 - HUBER RIZZO
Externo ao Programa - 384013 - LUCIO ESMERALDO HONORIO DE MELO
Externa ao Programa - 2073236 - SANDRA REGINA FONSECA DE ARAUJO VALENCA
Externa à Instituição - TATIANE RODRIGUES DA SILVA - UFCG
Externo à Instituição - EMANUEL FELIPE DE OLIVEIRA FILHO