Banca de QUALIFICAÇÃO: TAILE KATIELE SOUZA DE JESUS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : TAILE KATIELE SOUZA DE JESUS
DATE: 14/02/2022
TIME: 09:00
LOCAL: Google Meet (https://meet.google.com/iri-bpnr-kdk)
TITLE:

Iatrogenic poisoning by organophosphates in sheep

KEY WORDS:

Dichlorvos, intoxication, late neuropathy, ruminants

PAGES: 15
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Toxicologia Animal
SUMMARY:

The present work describes the death of fourteen Lacaune sheep, aged between three and nineteen months, which presented delayed polyneuropathy induced by organophosphates, after spontaneous intoxication by dichlorvos. 67 animals were exposed to environments disinfected daily with this chemical compound. The clinical signs observed were bradycardia, bronchoconstriction, diarrhea, salivation, nasal secretion, apathy, prostration, motor incoordination, pressure of the head against objects, neck stiffness, paresis, flaccid paralysis of the limbs, permanent recumbency and death. After the onset of clinical symptoms, the deaths occurred within an interval of forty days. Blood samples were collected for hepatic and renal evaluation, necropsy and toxicological examination of three and four animals, respectively. Hepatitis was observed in the serum biochemistry, pneumonia, congestion of the leptomeninges vessels, edema and pulmonary, pericardial and cerebral convolutions congestion in the anatomopathological analyses; hepatic macrosteatosis, hepatic and renal congestion, and central nervous system edema with white matter demyelination on histological analyses; and positivity for organophosphorus substances in pooled samples, analyzed by thin layer chromatography. It is concluded that the clinical epidemiological findings associated with the pathological and toxicological analyzes are consistent with the clinical course of a late neurotoxicity induced by organophosphates.

BANKING MEMBERS:
Presidente - 2073025 - HUBER RIZZO
Externo à Instituição - EMANUEL FELIPE DE OLIVEIRA FILHO
Externo à Instituição - SEBASTIÃO ANDRÉ BARBOSA JUNIOR