Banca de DEFESA: AYNA ARRAMIS APOLINARIO DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : AYNA ARRAMIS APOLINARIO DA SILVA
DATE: 14/01/2022
TIME: 10:00
LOCAL: Videoconferência
TITLE:

CONCENTRATION OF TROPONIN I AND CK-MB HEART ENZYMES IN OBESE DOGS

KEY WORDS:

Obesity; Canids; Metabolism; Clinical pathology; Heart Enzymes.

PAGES: 74
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Some problems commonly coexist in overweight and obese dogs, such as hyperglycemia, dyslipidemia, systemic arterial hypertension, insulin resistance, type 2 diabetes, among others, so that adiposity leads to the simultaneous development of these functional changes. Adipose tissue has become, currently, one of the main focuses of clinical research based on the understanding of the biological function of this tissue and its consequences on the physiology of different systems and organs. As the prevalence of obesity in dogs has increased sharply in recent years, generally related to the different modalities of diet and handling of animals, particularly those at home, it is necessary to understand the phenomena that occur in different systems, such as the cardiac, in addition to understanding of the relationship of existing comorbidities for the choice of semiotic, clinical and laboratory practices necessary for the proper diagnosis. Based on the above, the objective was to measure the activities of cardiac enzymes in dogs with and without obesity, in addition to biomarkers of energy, protein, mineral, enzymatic and endocrine activity. 52 dogs, aged between 8 months and 15 years, weighing between 11.2 and 60 kg, of different breeds and both sexes were used. The formation of experimental groups took place through nutritional assessment, body condition score, fat percentage and body mass index. Dogs were divided into three groups: control (16 animals); overweight (18 animals) and obese (18 animals). After an 8-hour fasting of food, 8 mL of blood were collected by jugular or cephalic venipuncture, being 2.0 mL in a tube with fluoride/EDTA and 6 ml in tubes with gel and clot activator. Dogs with obesity showed significant changes in the concentrations of triglycerides, cholesterol, albumin, Total Ca, Mg, in the HOMAR-IR and QUICK indices, in the Insulin:Glucose ratio and in the insulin concentration. The dynamics of serum troponin I concentration is related to the age of obese dogs, showing evidence that further investigations are needed to better elucidate obesity and insulin resistance in dogs influencing myocardial activity, using laboratory tests of capable biomarkers to detect and predict changes in cardiac muscle.

BANKING MEMBERS:
Presidente - 1088089 - PIERRE CASTRO SOARES
Externa ao Programa - 2240345 - EDNA MICHELLY DE SA SANTOS
Externa à Instituição - RENATA NOVAIS MENCALHA - UFRRJ
Externo à Instituição - DANIEL NUNES DE ARAUJO GONÇALVES - UFRPE