Banca de DEFESA: RAQUEL MOTA DE FREITAS PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RAQUEL MOTA DE FREITAS PEREIRA
DATE: 18/02/2022
TIME: 14:00
LOCAL: DMFA UFRPE
TITLE:

ANATOMOPATHOLOGICAL STUDY OF NEOPLASMS IN PET AND WILD RODENTS IN NORTHEASTERN BRAZIL

KEY WORDS:

Histopathology; wild mammals; Oncopathology; Rhodentia; Tumors.

PAGES: 91
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Patologia Animal
SPECIALTY: Anatomia Patologia Animal
SUMMARY:

Much of the scientific literature on tumors in rodents is based on induced neoplasms in rodents maintained as experimental models of human carcinogenesis. Works with spontaneous neoplasms in rodents kept as pets and wild rodents, especially in the northeast region of Brazil, are scarce. Thus, this dissertation comprises a literature review regarding the main spontaneous neoplasms reported in rodents and two scientific articles. The first article aims to describe the macroscopic, histopathological and immunohistochemical characteristics of spontaneous neoplasms in rodents kept as pets in a retrospective study, covering the years 2014 to 2021. The species involved in this study included hamsters, guinea pigs, rats and mice. Twenty-five neoplasms were diagnosed in 24 rodents. Hamsters were the most affected, followed by rats, guinea pigs and mice. Tegumentary neoplasms were the most common, followed by glandular, vascular, oral cavity and reproductive tract neoplasms. Neoplastic processes in geriatric animals were more frequent than in young animals. Breast neoplasms, myxoid neoplasms and lymphomas were the most common. Other tumors included hemangiosarcoma, squamous cell carcinoma, salivary adenoma, odor gland adenoma, adenocarcinoma, leiomyosarcoma, liposarcoma, perivascular wall tumor, pleomorphic sarcoma, fibrosarcoma, and histiocytic sarcoma. We observed that spontaneous neoplasms in pet rodents are common and that they resemble neoplasms already diagnosed in companion animals. Furthermore, the immunohistochemical markers used for neoplasms in domestic animals were efficient for these species. The second article aimed to describe the macroscopic and histopathological aspects of metastatic extramedullary plasmacytoma in a hedgehog (Coendou prehensilis). The animal, from the Dois Irmãos State Park, Recife-PE, was found dead in the enclosure. At necropsy, a mass involving the aorta, cranial vena cava, trachea and esophagus was found at the level of the mediastinum. Multiple nodules were also present in the duodenum and renal parenchyma. Histopathological examination of the mass revealed a densely cellular round cell neoplasm with abundant eosinophilic and granular cytoplasm. The cores were decentralized with a “wagon wheel” pattern. This same cellularity was observed in the duodenum, spleen, lymph nodes and kidneys. This is the first report of plasmacytoma in a porcupine species.

BANKING MEMBERS:
Presidente - 1628479 - FABIO DE SOUZA MENDONCA
Interno - 1929164 - FRANCISCO DE ASSIS LEITE SOUZA
Externa à Instituição - PAULA ROBERTA GIARETTA